By helping the neurosurgeon create treatment strategies that increase the survival rate, automotive diagnosis and CT (Computed Tomography) hemorrhage segmentation (CT) could be beneficial. Owing to the significance of medical image segmentation and the difficulties in carrying out human operations, a wide variety of automated techniques for this purpose have been developed, with a primary focus on particular image modalities. In this paper, MUNet (Multiclass-UNet) based Intracranial Hemorrhage Segmentation and Classification Framework (IHSNet) is proposed to successfully segment multiple kinds of hemorrhages while the fully connected layers help in classifying the type of hemorrhages.The segmentation accuracy rates for hemorrhages are 98.53% with classification accuracy stands at 98.71% when using the suggested approach. There is potential for this suggested approach to be expanded in the future to handle further medical picture segmentation issues. Intraventricular hemorrhage (IVH), Epidural hemorrhage (EDH), Intraparenchymal hemorrhage (IPH), Subdural hemorrhage (SDH), Subarachnoid hemorrhage (SAH) are the subtypes involved in intracranial hemorrhage (ICH) whose DICE coefficients are 0.77, 0.84, 0.64, 0.80, and 0.92 respectively.The proposed method has great deal of clinical application potential for computer-aided diagnostics, which can be expanded in the future to handle further medical picture segmentation and to tackle with the involved issues.

The recent approval of anti-amyloid pharmaceuticals for the treatment of Alzheimer's disease (AD) has created a pressing need for the ability to accurately identify optimal candidates for anti-amyloid therapy, specifically those with evidence for incipient cognitive decline, since patients with mild cognitive impairment (MCI) may remain stable for several years even with positive AD biomarkers. Using fluorodeoxyglucose PET and biomarker data from 594 ADNI patients, a neural network ensemble was trained to forecast cognition from MCI diagnostic baseline. Training data comprised PET studies of patients with biological AD. The ensemble discriminated between progressive and stable prodromal subjects (MCI with positive amyloid and tau) at baseline with 88.6% area-under-curve, 88.6% (39/44) accuracy, 73.7% (14/19) sensitivity and 100% (25/25) specificity in the test set. It also correctly classified all other test subjects (healthy or AD continuum subjects across the cognitive spectrum) with 86.4% accuracy (206/239), 77.4% sensitivity (33/42) and 88.23% (165/197) specificity. By identifying patients with prodromal AD who will not progress to dementia, our model could significantly reduce overall societal burden and cost if implemented as a screening tool. The model's high positive predictive value in the prodromal test set makes it a practical means for selecting candidates for anti-amyloid therapy and trials.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that severely affects memory, behavior, and cognitive function. Early and accurate diagnosis is crucial for effective intervention, yet detecting subtle changes in the early stages remains a challenge. In this study, we propose a hybrid deep learning-based multi-class classification system for AD using magnetic resonance imaging (MRI). The proposed approach integrates an improved DeepLabV3+ (IDeepLabV3+) model for lesion segmentation, followed by feature extraction using the LeNet-5 model. A novel feature selection method based on average correlation and error probability is employed to enhance classification efficiency. Finally, an Enhanced ResNext (EResNext) model is used to classify AD into four stages: non-dementia (ND), very mild dementia (VMD), mild dementia (MD), and moderate dementia (MOD). The proposed model achieves an accuracy of 98.12%, demonstrating its superior performance over existing methods. The area under the ROC curve (AUC) further validates its effectiveness, with the highest score of 0.97 for moderate dementia. This study highlights the potential of hybrid deep learning models in improving early AD detection and staging, contributing to more accurate clinical diagnosis and better patient care.

Accurate differentiation of pseudoprogression (PsP) from True Progression (TP) following radiotherapy (RT) in glioblastoma patients is crucial for optimal treatment planning. However, this task remains challenging due to the overlapping imaging characteristics of PsP and TP. This study therefore proposes a multimodal deep-learning approach utilizing complementary information from routine anatomical MR images, clinical parameters, and RT treatment planning information for improved predictive accuracy. The approach utilizes a self-supervised Vision Transformer (ViT) to encode multi-sequence MR brain volumes to effectively capture both global and local context from the high dimensional input. The encoder is trained in a self-supervised upstream task on unlabeled glioma MRI datasets from the open BraTS2021, UPenn-GBM, and UCSF-PDGM datasets (n = 2317 MRI studies) to generate compact, clinically relevant representations from FLAIR and T1 post-contrast sequences. These encoded MR inputs are then integrated with clinical data and RT treatment planning information through guided cross-modal attention, improving progression classification accuracy. This work was developed using two datasets from different centers: the Burdenko Glioblastoma Progression Dataset (n = 59) for training and validation, and the GlioCMV progression dataset from the University Hospital Erlangen (UKER) (n = 20) for testing. The proposed method achieved competitive performance, with an AUC of 75.3%, outperforming the current state-of-the-art data-driven approaches. Importantly, the proposed approach relies solely on readily available anatomical MRI sequences, clinical data, and RT treatment planning information, enhancing its clinical feasibility. The proposed approach addresses the challenge of limited data availability for PsP and TP differentiation and could allow for improved clinical decision-making and optimized treatment plans for glioblastoma patients.

The application of AI for predicting critical heart failure endpoints using echocardiography is a promising avenue to improve patient care and treatment planning. However, fully supervised training of deep learning models in medical imaging requires a substantial amount of labelled data, posing significant challenges due to the need for skilled medical professionals to annotate image sequences. Our study addresses this limitation by exploring the potential of self-supervised learning, emphasising interpretability, robustness, and safety as crucial factors in cardiac imaging analysis. We leverage self-supervised learning on a large unlabelled dataset, facilitating the discovery of features applicable to a various downstream tasks. The backbone model not only generates informative features for training smaller models using simple techniques but also produces features that are interpretable by humans. The study employs a modified Self-supervised Transformer with Energy-based Graph Optimisation (STEGO) network on top of self-DIstillation with NO labels (DINO) as a backbone model, pre-trained on diverse medical and non-medical data. This approach facilitates the generation of self-segmented outputs, termed "parcels", which identify distinct anatomical sub-regions of the heart. Our findings highlight the robustness of these self-learned parcels across diverse patient profiles and phases of the cardiac cycle phases. Moreover, these parcels offer high interpretability and effectively encapsulate clinically relevant cardiac substructures. We conduct a comprehensive evaluation of the proposed self-supervised approach on publicly available datasets, demonstrating its adaptability to a wide range of requirements. Our results underscore the potential of self-supervised learning to address labelled data scarcity in medical imaging, offering a path to improve cardiac imaging analysis and enhance the efficiency and interpretability of diagnostic procedures, thus positively impacting patient care and clinical decision-making.

Craniomaxillofacial (CMF) surgery addresses complex challenges, balancing aesthetic and functional restoration. Digital technologies, including advanced imaging, virtual surgical planning, computer-aided design, and 3D printing, have revolutionized this field. These tools improve accuracy and optimize processes across all surgical phases, from diagnosis to postoperative evaluation. CMF's unique demands are met through patient-specific solutions that optimize outcomes. Emerging technologies like artificial intelligence, extended reality, robotics, and bioprinting promise to overcome limitations, driving the future of personalized, technology-driven CMF care.

This study evaluates the performance, cost, and processing time of OpenAI's reasoning large language models (LLMs) (o1-preview, o1-mini) and their base models (GPT-4o, GPT-4o-mini) on Japanese radiology board examination questions. A total of 210 questions from the 2022-2023 official board examinations of the Japan Radiological Society were presented to each of the four LLMs. Performance was evaluated by calculating the percentage of correctly answered questions within six predefined radiology subspecialties. The total cost and processing time for each model were also recorded. The McNemar test was used to assess the statistical significance of differences in accuracy between paired model responses. The o1-preview achieved the highest accuracy (85.7%), significantly outperforming GPT-4o (73.3%, P<.001). Similarly, o1-mini (69.5%) performed significantly better than GPT-4o-mini (46.7%, P<.001). Across all radiology subspecialties, o1-preview consistently ranked highest. However, reasoning models incurred substantially higher costs (o1-preview: $17.10, o1-mini: $2.58) compared to their base counterparts (GPT-4o: $0.496, GPT-4o-mini: $0.04), and their processing times were approximately 3.7 and 1.2 times longer, respectively. Reasoning LLMs demonstrated markedly superior performance in answering radiology board exam questions compared to their base models, albeit at a substantially higher cost and increased processing time.

Identifying systemic disease with medical imaging studies may improve population health outcomes. Although the pathogenesis of peripheral arterial calcification and coronary artery calcification differ, breast arterial calcification (BAC) on mammography is associated with cardiovascular disease (CVD), a leading cause of death in women. While professional society guidelines on the reporting or management of BAC have not yet been established, and assessment and quantification methods are not yet standardized, the value of reporting BAC is being considered internationally as a possible indicator of subclinical CVD. Furthermore, artificial intelligence (AI) models are being developed to identify and quantify BAC on mammography, as well as to predict the risk of CVD. This review outlines studies evaluating the association of BAC and CVD, introduces the role of preventative cardiology in clinical management, discusses reasons to consider reporting BAC, acknowledges current knowledge gaps and barriers to assessing and reporting calcifications, and provides examples of how AI can be utilized to measure BAC and contribute to cardiovascular risk assessment. Ultimately, reporting BAC on mammography might facilitate earlier mitigation of cardiovascular risk factors in asymptomatic women.

Medical image segmentation relies heavily on convolutional neural networks (CNNs) and Transformer-based models. However, CNNs are constrained by limited receptive fields, while Transformers suffer from scalability challenges due to their quadratic computational complexity. To address these limitations, recent advances have explored alternative architectures. The state-space model Mamba offers near-linear complexity while capturing long-range dependencies, and the Kolmogorov-Arnold Network (KAN) enhances nonlinear expressiveness by replacing fixed activation functions with learnable ones. Building on these strengths, we propose MedVKAN, an efficient feature extraction model integrating Mamba and KAN. Specifically, we introduce the EFC-KAN module, which enhances KAN with convolutional operations to improve local pixel interaction. We further design the VKAN module, integrating Mamba with EFC-KAN as a replacement for Transformer modules, significantly improving feature extraction. Extensive experiments on five public medical image segmentation datasets show that MedVKAN achieves state-of-the-art performance on four datasets and ranks second on the remaining one. These results validate the potential of Mamba and KAN for medical image segmentation while introducing an innovative and computationally efficient feature extraction framework. The code is available at: https://github.com/beginner-cjh/MedVKAN.

Condylar remodeling is a key prognostic indicator in maxillofacial surgery for skeletal class II patients. This study aimed to develop and validate a fully automated method leveraging landmark-guided segmentation and registration for efficient assessment of condylar remodeling. A V-Net-based deep learning workflow was developed to automatically segment the mandible and localize anatomical landmarks from CT images. Cutting planes were computed based on the landmarks to segment the condylar and ramus volumes from the mandible mask. The stable ramus served as a reference for registering pre- and post-operative condyles using the Iterative Closest Point (ICP) algorithm. Condylar remodeling was subsequently assessed through mesh registration, heatmap visualization, and quantitative metrics of surface distance and volumetric change. Experts also rated the concordance between automated assessments and clinical diagnoses. In the test set, condylar segmentation achieved a Dice coefficient of 0.98, and landmark prediction yielded a mean absolute error of 0.26 mm. The automated evaluation process was completed in 5.22 seconds, approximately 150 times faster than manual assessments. The method accurately quantified condylar volume changes, ranging from 2.74% to 50.67% across patients. Expert ratings for all test cases averaged 9.62. This study introduced a consistent, accurate, and fully automated approach for condylar remodeling evaluation. The well-defined anatomical landmarks guided precise segmentation and registration, while deep learning supported an end-to-end automated workflow. The test results demonstrated its broad clinical applicability across various degrees of condylar remodeling and high concordance with expert assessments. By integrating anatomical landmarks and deep learning, the proposed method improves efficiency by 150 times without compromising accuracy, thereby facilitating an efficient and accurate assessment of orthognathic prognosis. The personalized 3D condylar remodeling models aid in visualizing sequelae, such as joint pain or skeletal relapse, and guide individualized management of TMJ disorders.