This study presents an unsupervised, motion-resolved reconstruction framework for high-resolution, free-breathing pulmonary magnetic resonance imaging (MRI), utilizing a three-dimensional Gaussian representation (3DGS). The proposed method leverages 3DGS to address the challenges of motion-resolved 3D isotropic pulmonary MRI reconstruction by enabling data smoothing between voxels for continuous spatial representation. Pulmonary MRI data acquisition is performed using a golden-angle radial sampling trajectory, with respiratory motion signals extracted from the center of k-space in each radial spoke. Based on the estimated motion signal, the k-space data is sorted into multiple respiratory phases. A 3DGS framework is then applied to reconstruct a reference image volume from the first motion state. Subsequently, a patient-specific convolutional neural network is trained to estimate the deformation vector fields (DVFs), which are used to generate the remaining motion states through spatial transformation of the reference volume. The proposed reconstruction pipeline is evaluated on six datasets from six subjects and bench-marked against three state-of-the-art reconstruction methods. The experimental findings demonstrate that the proposed reconstruction framework effectively reconstructs high-resolution, motion-resolved pulmonary MR images. Compared with existing approaches, it achieves superior image quality, reflected by higher signal-to-noise ratio and contrast-to-noise ratio. The proposed unsupervised 3DGS-based reconstruction method enables accurate motion-resolved pulmonary MRI with isotropic spatial resolution. Its superior performance in image quality metrics over state-of-the-art methods highlights its potential as a robust solution for clinical pulmonary MR imaging.

Fast PET imaging is clinically important for reducing motion artifacts and improving patient comfort. While recent diffusion-based deep learning methods have shown promise, they often fail to capture the true PET degradation process, suffer from accumulated inference errors, introduce artifacts, and require extensive reconstruction iterations. To address these challenges, we propose a novel multistage diffusion framework tailored for fast PET imaging. At the coarse level, we design a multistage structure to approximate the temporal non-linear PET degradation process in a data-driven manner, using paired PET images collected under different acquisition duration. A Phase Error Correction Network (PECNet) ensures consistency across stages by correcting accumulated deviations. At the fine level, we introduce a deterministic cold diffusion mechanism, which simulates intra-stage degradation through interpolation between known acquisition durations-significantly reducing reconstruction iterations to as few as 10. Evaluations on [⁶⁸Ga]FAPI and [¹⁸F]FDG PET datasets demonstrate the superiority of our approach, achieving peak PSNRs of 36.2 dB and 39.0 dB, respectively, with average SSIMs over 0.97. Our framework offers high-fidelity PET imaging with fewer iterations, making it practical for accelerated clinical imaging.

Recent advances in deep learning-based parallel compressed sensing magnetic resonance imaging (p-CSMRI) have significantly improved reconstruction quality. However, current p-CSMRI methods often require training separate deep neural network (DNN) for each organ due to anatomical variations, creating a barrier to developing generalized medical image reconstruction systems. To address this, we propose CAPNet (cross-organ all-in-one deep unfolding p-CSMRI network), a unified framework that implements a p-CSMRI iterative algorithm via three specialized modules: auxiliary variable module, prior module, and data consistency module. Recognizing that p-CSMRI systems often employ varying sampling ratios for different organs, resulting in organ-specific artifact patterns, we introduce an artifact generation submodule, which extracts and integrates artifact features into the data consistency module to enhance the discriminative capability of the overall network. For the prior module, we design an organ structure-prompt generation submodule that leverages structural features extracted from the segment anything model (SAM) to create cross-organ prompts. These prompts are strategically incorporated into the prior module through an organ structure-aware Mamba submodule. Comprehensive evaluations on a cross-organ dataset confirm that CAPNet achieves state-of-the-art reconstruction performance across multiple anatomical structures using a single unified model. Our code will be published at https://github.com/shibaoshun/CAPNet.

In compressed sensing (CS) MRI, model-based methods are pivotal to achieving accurate reconstruction. One of the main challenges in model-based methods is finding an effective prior to describe the statistical distribution of the target image. Plug-and-Play (PnP) and REgularization by Denoising (RED) are two general frameworks that use denoisers as the prior. While PnP/RED methods with convolutional neural networks (CNNs) based denoisers outperform classical hand-crafted priors in CS MRI, their convergence theory relies on assumptions that do not hold for practical CNNs. The recently developed gradient-driven denoisers offer a framework that bridges the gap between practical performance and theoretical guarantees. However, the numerical solvers for the associated minimization problem remain slow for CS MRI reconstruction. This paper proposes a complex quasi-Newton proximal method that achieves faster convergence than existing approaches. To address the complex domain in CS MRI, we propose a modified Hessian estimation method that guarantees Hermitian positive definiteness. Furthermore, we provide a rigorous convergence analysis of the proposed method for nonconvex settings. Numerical experiments on both Cartesian and non-Cartesian sampling trajectories demonstrate the effectiveness and efficiency of our approach.

Efficient evaluation of soft tissues and bony structures following cervical spine trauma is critical. We sought to evaluate the diagnostic validity of magnetic resonance imaging (MRI)-based synthetic CT (sCT) compared with conventional computed tomography (CT) for cervical spine injuries. In a prospective, multicenter study, patients with cervical spine injuries underwent CT and MRI within 48 h after injury. A panel of five clinicians independently reviewed the images for diagnostic accuracy, lesion characterization (AO Spine classification), and soft tissue trauma. Fracture visibility, anterior (AVH) and posterior wall height (PVH), vertebral body angle (VBA), segmental kyphosis (SK), with corresponding interobserver reliability (intraclass correlation coefficients (ICC)) and intermodal differences (Fleiss' Kappa), were recorded. The accuracy of estimating Hounsfield unit (HU) values and mean cortical surface distances were measured. Thirty-seven patients (44 cervical spine fractures) were enrolled. sCT demonstrated a sensitivity of 97.3% for visualizing fractures. Intermodal agreement regarding injury classification indicated almost perfect agreement (κ = 0.922; p < 0.001). Inter-reader ICCs were good to excellent (CT vs. sCT): AVH (0.88, 0.87); PVH (0.87, 0.88); VBA (0.78, 0.76); SK (0.77, 0.93). Intermodal agreement showed a mean absolute difference of 0.3 mm (AVH), 0.3 mm (PVH), 1.15° (VBA) and 0.51° (SK), respectively. MRI visualized additional soft tissue trauma in 56.8% of patients. Voxelwise comparisons of sCT showed good to excellent agreement with CT in terms of HUs (mean absolute error of 20 (SD ± 62)) and a mean absolute cortical surface distance of 0.45 mm (SD ± 0.13). sCT is a promising, radiation-free imaging technique for diagnosing cervical spine injuries with similar accuracy to CT. Question Assessing the accuracy of MRI-based synthetic CT (sCT) for fracture visualization and classification in comparison to the gold standard of CT for cervical spine injuries. Findings sCT demonstrated a 97.3% sensitivity in detecting fractures and exhibited near-perfect intermodal agreement in classifying injuries according to the AO Spine classification system. Clinical relevance sCT is a promising, radiation-free imaging modality that offers comparable accuracy to CT in visualizing and classifying cervical spine injuries. The combination of conventional MRI sequences for soft tissue evaluation with sCT reconstruction for bone visualization provides comprehensive diagnostic information.

Artificial intelligence (AI) is now transforming medical imaging, with extensive ramifications for nearly every aspect of diagnostic imaging, including computed tomography (CT). This current work aims to review, evaluate, and summarise the role of AI in radiation dose optimisation across three fundamental domains in CT: patient positioning, scan range determination, and image reconstruction. A comprehensive scoping review of the literature was performed. Electronic databases including Scopus, Ovid, EBSCOhost and PubMed were searched between January 2018 and December 2024. Relevant articles were identified from their titles had their abstracts evaluated, and those deemed relevant had their full text reviewed. Extracted data from selected studies included the application of AI, radiation dose, anatomical part, and any relevant evaluation metrics based on the CT parameter in which AI is applied. 90 articles met the selection criteria. Included studies evaluated the performance of AI for dose optimisation through patient positioning, scan range determination, and reconstruction across various CT scans, including the abdomen, chest, head, neck, and pelvis, as well as CT angiography. A concise overview of the present state of AI in these three domains, emphasising benefits, limitations, and impact on the transformation of dose reduction in CT scanning, is provided. AI methods can help minimise positioning offsets and over-scanning caused by manual errors and helped to overcome the limitation associated with low-dose CT settings through deep learning image reconstruction algorithms. Further clinical integration of AI will continue to allow for improvements in optimising CT scan protocols and radiation dose. This review underscores the significance of AI in optimizing radiation doses in CT imaging, focusing on three key areas: patient positioning, scan range determination, and image reconstruction.

The translation of imaging Mueller polarimetry to clinical practice is often hindered by large footprint and relatively slow acquisition speed of the existing instruments. Using polarization-sensitive camera as a detector may reduce instrument dimensions and allow data streaming at video rate. However, only the first three rows of a complete 4×4 Mueller matrix can be measured. To overcome this hurdle we developed a machine learning approach using sequential neural network algorithm for the reconstruction of missing elements of a Mueller matrix from the measured elements of the first three rows. The algorithm was trained and tested on the dataset of polarimetric images of various excised human tissues (uterine cervix, colon, skin, brain) acquired with two different imaging Mueller polarimeters operating in either reflection (wide-field imaging system) or transmission (microscope) configurations at different wavelengths of 550 nm and 385 nm, respectively. Reconstruction performance was evaluated using various error metrics, all of which confirmed low error values. The reconstruction of full images of the fourth row of Mueller matrix with GPU parallelization and increasing batch size took less than 50 milliseconds. It suggests that a machine learning approach with parallel processing of all image pixels combined with the partial Mueller polarimeter operating at video rate can effectively substitute for the complete Mueller polarimeter and produce accurate maps of depolarization, linear retardance and orientation of the optical axis of biological tissues, which can be used for medical diagnosis in clinical settings.

Dynamic computed tomography (CT) reconstruction faces significant challenges in addressing motion artifacts, particularly for nonperiodic rapid movements such as cardiac imaging with fast heart rates. Traditional methods struggle with the extreme limited-angle problems inherent in nonperiodic cases. Deep learning methods have improved performance but face generalization challenges. Recent implicit neural representation (INR) techniques show promise through self-supervised deep learning, but have critical limitations: computational inefficiency due to forward-warping modeling, difficulty balancing DVF complexity with anatomical plausibility, and challenges in preserving fine details without additional patient-specific pre-scans. This paper presents a novel INR-based framework, BIRD, for nonperiodic dynamic CT reconstruction. It addresses these challenges through four key contributions: (1) backward-warping deformation that enables direct computation of each dynamic voxel with significantly reduced computational cost, (2) diffeomorphism-based DVF regularization that ensures anatomically plausible deformations while maintaining representational capacity, (3) motion-compensated analytical reconstruction that enhances fine details without requiring additional pre-scans, and (4) dimensional-reduction design for efficient 4D coordinate encoding. Through various simulations and practical studies, including digital and physical phantoms and retrospective patient data, we demonstrate the effectiveness of our approach for nonperiodic dynamic CT reconstruction with enhanced details and reduced motion artifacts. The proposed framework enables more accurate dynamic CT reconstruction with potential clinical applications, such as one-beat cardiac reconstruction, cinematic image sequences for functional imaging, and motion artifact reduction in conventional CT scans.

Dopamine transporter (DAT) SPECT is an effective tool for early Parkinson's disease (PD) detection and heavily hampered by attenuation. Attenuation correction (AC) is the most important correction among other corrections. Transfer learning (TL) with fine-tuning (FT) a pre-trained model has shown potential in enhancing deep learning (DL)-based AC methods. In this study, we investigate leveraging realistic Monte Carlo (MC) simulation data to create a pre-trained model for TL-based AC (TLAC) to improve AC performance for DAT SPECT. A total number of 200 digital brain phantoms with realistic ^99mTc-TRODAT-1 distribution was used to generate realistic noisy SPECT projections using MC SIMIND program and an analytical projector. One hundred real clinical ^99mTc-TRODAT-1 brain SPECT data were also retrospectively analyzed. All projections were reconstructed with and without CT-based attenuation correction (CTAC/NAC). A 3D conditional generative adversarial network (cGAN) was pre-trained using 200 pairs of simulated NAC and CTAC SPECT data. Subsequently, 8, 24, and 80 pairs of clinical NAC and CTAC DAT SPECT data were employed to fine-tune the pre-trained U-Net generator of cGAN (TLAC-MC). Comparisons were made against without FT (DLAC-MC), training on purely limited clinical data (DLAC-CLI), clinical data with data augmentation (DLAC-AUG), mixed MC and clinical data (DLAC-MIX), TL using analytical simulation data (TLAC-ANA), and Chang's AC (ChangAC). All datasets used for DL-based methods were split to 7/8 for training and 1/8 for validation, and a 1-/2-/5-fold cross-validation were applied to test all 100 clinical datasets, depending on the numbers of clinical data used in the training model. With 8 available clinical datasets, TLAC-MC achieved the best result in Normalized Mean Squared Error (NMSE) and Structural Similarity Index Measure (SSIM) (TLAC-MC; NMSE = 0.0143 ± 0.0082/SSIM = 0.9355 ± 0.0203), followed by DLAC-AUG, DLAC-MIX, TLAC-ANA, DLAC-CLI, DLAC-MC, ChangAC and NAC. Similar trends exist when increasing the number of clinical datasets. For TL-based AC methods, the fewer clinical datasets available for FT, the greater the improvement as compared to DLAC-CLI using the same number of clinical datasets for training. Joint histograms analysis and Bland-Altman plots of SBR results also demonstrate consistent findings. TLAC is feasible for DAT SPECT with a pre-trained model generated purely based on simulation data. TLAC-MC demonstrates superior performance over other DL-based AC methods, particularly when limited clinical datasets are available. The closer the pre-training data is to the target domain, the better the performance of the TLAC model.

Active stress models in cardiac biomechanics account for the mechanical deformation caused by muscle activity, thus providing a link between the electrophysiological and mechanical properties of the tissue. The accurate assessment of active stress parameters is fundamental for a precise understanding of myocardial function but remains difficult to achieve in a clinical setting, especially when only displacement and strain data from medical imaging modalities are available. This work investigates, through an in-silico study, the application of physics-informed neural networks (PINNs) for inferring active contractility parameters in time-dependent cardiac biomechanical models from these types of imaging data. In particular, by parametrising the sought state and parameter field with two neural networks, respectively, and formulating an energy minimisation problem to search for the optimal network parameters, we are able to reconstruct in various settings active stress fields in the presence of noise and with a high spatial resolution. To this end, we also advance the vanilla PINN learning algorithm with the use of adaptive weighting schemes, ad-hoc regularisation strategies, Fourier features, and suitable network architectures. In addition, we thoroughly analyse the influence of the loss weights in the reconstruction of active stress parameters. Finally, we apply the method to the characterisation of tissue inhomogeneities and detection of fibrotic scars in myocardial tissue. This approach opens a new pathway to significantly improve the diagnosis, treatment planning, and management of heart conditions associated with cardiac fibrosis.