Identifying brain hemorrhages from magnetic resonance imaging (MRI) is a critical task for healthcare professionals. The diverse nature of MRI acquisitions with varying contrasts and orientation introduce complexity in identifying hemorrhage using neural networks. For acquisitions with varying orientations, traditional methods often involve resampling images to a fixed plane, which can lead to information loss. To address this, we propose a 3D multi-plane vision transformer (MP-ViT) for hemorrhage classification with varying orientation data. It employs two separate transformer encoders for axial and sagittal contrasts, using cross-attention to integrate information across orientations. MP-ViT also includes a modality indication vector to provide missing contrast information to the model. The effectiveness of the proposed model is demonstrated with extensive experiments on real world clinical dataset consists of 10,084 training, 1,289 validation and 1,496 test subjects. MP-ViT achieved substantial improvement in area under the curve (AUC), outperforming the vision transformer (ViT) by 5.5% and CNN-based architectures by 1.8%. These results highlight the potential of MP-ViT in improving performance for hemorrhage detection when different orientation contrasts are needed.

Multi-material decomposition (MMD) enables quantitative reconstruction of tissue compositions in the human body, supporting a wide range of clinical applications. However, traditional MMD typically requires spectral CT scanners and pre-measured X-ray energy spectra, significantly limiting clinical applicability. To this end, various methods have been developed to perform MMD using conventional (i.e., single-energy, SE) CT systems, commonly referred to as SEMMD. Despite promising progress, most SEMMD methods follow a two-step image decomposition pipeline, which first reconstructs monochromatic CT images using algorithms such as FBP, and then performs decomposition on these images. The initial reconstruction step, however, neglects the energy-dependent attenuation of human tissues, introducing severe nonlinear beam hardening artifacts and noise into the subsequent decomposition. This paper proposes JSover, a fundamentally reformulated one-step SEMMD framework that jointly reconstructs multi-material compositions and estimates the energy spectrum directly from SECT projections. By explicitly incorporating physics-informed spectral priors into the SEMMD process, JSover accurately simulates a virtual spectral CT system from SE acquisitions, thereby improving the reliability and accuracy of decomposition. Furthermore, we introduce implicit neural representation (INR) as an unsupervised deep learning solver for representing the underlying material maps. The inductive bias of INR toward continuous image patterns constrains the solution space and further enhances estimation quality. Extensive experiments on both simulated and real CT datasets show that JSover outperforms state-of-the-art SEMMD methods in accuracy and computational efficiency.

Breast cancer is the most frequently diagnosed human cancer in the United States at present. Early detection is crucial for its successful treatment. X-ray mammography and digital breast tomosynthesis are currently the main methods for breast cancer screening. However, both have known limitations in terms of their sensitivity and specificity to breast cancers, while also frequently causing patient discomfort due to the requirement for breast compression. Breast computed tomography is a promising alternative, however, to obtain high-quality images, the X-ray dose needs to be sufficiently high. As the breast is highly radiosensitive, dose reduction is particularly important. Phase-contrast computed tomography (PCT) has been shown to produce higher-quality images at lower doses and has no need for breast compression. It is demonstrated in the present study that, when imaging full fresh mastectomy samples with PCT, deep learning-based image denoising can further reduce the radiation dose by a factor of 16 or more, without any loss of image quality. The image quality has been assessed both in terms of objective metrics, such as spatial resolution and contrast-to-noise ratio, as well as in an observer study by experienced medical imaging specialists and radiologists. This work was carried out in preparation for live patient PCT breast cancer imaging, initially at specialized synchrotron facilities.

Early detection and accurate diagnosis are essential to improving patient outcomes. The use of convolutional neural networks (CNNs) for tumor detection has shown promise, but existing models often suffer from overparameterization, which limits their performance gains. In this study, fuzzy sigmoid convolution (FSC) is introduced along with two additional modules: top-of-the-funnel and middle-of-the-funnel. The proposed methodology significantly reduces the number of trainable parameters without compromising classification accuracy. A novel convolutional operator is central to this approach, effectively dilating the receptive field while preserving input data integrity. This enables efficient feature map reduction and enhances the model's tumor detection capability. In the FSC-based model, fuzzy sigmoid activation functions are incorporated within convolutional layers to improve feature extraction and classification. The inclusion of fuzzy logic into the architecture improves its adaptability and robustness. Extensive experiments on three benchmark datasets demonstrate the superior performance and efficiency of the proposed model. The FSC-based architecture achieved classification accuracies of 99.17%, 99.75%, and 99.89% on three different datasets. The model employs 100 times fewer parameters than large-scale transfer learning architectures, highlighting its computational efficiency and suitability for detecting brain tumors early. This research offers lightweight, high-performance deep-learning models for medical imaging applications.

Recent advances in deep learning-based parallel compressed sensing magnetic resonance imaging (p-CSMRI) have significantly improved reconstruction quality. However, current p-CSMRI methods often require training separate deep neural network (DNN) for each organ due to anatomical variations, creating a barrier to developing generalized medical image reconstruction systems. To address this, we propose CAPNet (cross-organ all-in-one deep unfolding p-CSMRI network), a unified framework that implements a p-CSMRI iterative algorithm via three specialized modules: auxiliary variable module, prior module, and data consistency module. Recognizing that p-CSMRI systems often employ varying sampling ratios for different organs, resulting in organ-specific artifact patterns, we introduce an artifact generation submodule, which extracts and integrates artifact features into the data consistency module to enhance the discriminative capability of the overall network. For the prior module, we design an organ structure-prompt generation submodule that leverages structural features extracted from the segment anything model (SAM) to create cross-organ prompts. These prompts are strategically incorporated into the prior module through an organ structure-aware Mamba submodule. Comprehensive evaluations on a cross-organ dataset confirm that CAPNet achieves state-of-the-art reconstruction performance across multiple anatomical structures using a single unified model. Our code will be published at https://github.com/shibaoshun/CAPNet.

Magnetic Resonance Imaging (MRI) is the gold standard in countless diagnostic procedures, yet hardware complexity, long scans, and cost preclude rapid screening and point-of-care use. We introduce Imageless Magnetic Resonance Diagnosis (IMRD), a framework that bypasses k-space sampling and image reconstruction by analyzing raw one-dimensional MR signals. We identify potentially impactful embodiments where IMRD requires only optimized pulse sequences for time-domain contrast, minimal low-field hardware, and pattern recognition algorithms to answer clinical closed queries and quantify lesion burden. As a proof of concept, we simulate multiple sclerosis lesions in silico within brain phantoms and deploy two extremely fast protocols (approximately 3 s), with and without spatial information. A 1D convolutional neural network achieves AUC close to 0.95 for lesion detection and R2 close to 0.99 for volume estimation. We also perform robustness tests under reduced signal-to-noise ratio, partial signal omission, and relaxation-time variability. By reframing MR signals as direct diagnostic metrics, IMRD paves the way for fast, low-cost MR screening and monitoring in resource-limited environments.