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A multimodal foundation model for emergency head CT interpretation

July 9, 2026medrxiv logopreprint

Authors

Zheng, J.,Chen, Y.,Wu, B.,Wang, Y.,Liu, M.,Li, L.,Jiang, S.,Chen, W.,Xu, L.,Wu, Y.,Liu, C.,Guo, L.,Bai, X.,Li, Z.,Yang, H.,Qin, F.,Liu, J.,Qu, H.,Liao, Q.,Zhao, G.,Pan, K.,Guo, J.,Chen, L.,Zhou, Y.,Sun, H.,Tian, Q.

Affiliations (1)

  • Tsinghua University

Abstract

Non-contrast head CT is the first-line imaging modality for acute neurological emergencies, with demand rising worldwide. However, existing foundation models for head CT interpretation are ill-suited for emergency use because they target general or chronic-disease assessment and optimize reports for lexical overlap rather than the risk-relevant findings central to emergency triage. Here we present CHIEF, a Chinese-language Head CT Interpretation Emergency Foundation model, pretrained on emergency head CT volumes and paired reports with contrastive, generative, and geometry-regularization objectives. Trained and evaluated on 16,563 examinations from seven hospitals, CHIEF achieved an AUROC of 0.9646 for emergency triage and drafted triage-oriented radiology reports, while also supporting image-to-text retrieval for reference-case support and zero-shot abnormality recognition. CHIEF generated reports of substantially higher quality than those from commercial multimodal large language models, which could not be reliably distinguished from human-written ones by radiologists in a blinded Turing test. Overall, CHIEF provides a generalizable foundation for emergency head CT interpretation and radiologist-in-the-loop clinical decision support.

Topics

health informatics

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