From Genome to Phenome: Opportunities and Challenges of Molecular Imaging.
Authors
Affiliations (11)
Affiliations (11)
- Huashan Hospital and Human Phenome Institute, Fudan University, Shanghai, China; [email protected] [email protected].
- Institute for Systems Biology, Seattle, Washington.
- Vita-Salute San Raffaele University, Milan, Italy.
- IRCCS San Raffaele, Milan, Italy.
- School of Medicine and Health, Technical University of Munich, Munich, Germany.
- Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, Utah.
- RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.
- Kobe University Graduate School of Science, Technology and Innovation, Kobe, Japan.
- Seoul National University Hospital, Seoul, Republic of Korea.
- College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China; and [email protected] [email protected].
- Department of Nuclear Medicine, Second Affiliated Hospital of Zhejiang University, Hangzhou, China.
Abstract
The study of the human phenome is essential for understanding the complexities of wellness and disease and their transitions, with molecular imaging being a vital tool in this exploration. Molecular imaging embodies the 4 principles of human phenomics: precise measurement, accurate calculation or analysis, well-controlled manipulation or intervention, and innovative invention or creation. Its application has significantly enhanced the precision, individualization, and effectiveness of medical interventions. This article provides an overview of molecular imaging's technologic advancements and presents the potential use of molecular imaging in human phenomics and precision medicine. The integration of molecular imaging with multiomics data and artificial intelligence has the potential to transform health care, promoting proactive and preventive strategies. This evolving approach promises to deepen our understanding of the human phenome, lead to preclinical diagnostics and treatments, and establish quantitative frameworks for precision health management.