MSA-Net: a multi-scale and adversarial learning network for segmenting bone metastases in low-resolution SPECT imaging.
Authors
Affiliations (8)
Affiliations (8)
- Key Laboratory of China's Ethnic Languages and Information Technology of Ministry of Education, Northwest Minzu University, Lanzhou, Gansu, China.
- School of Mathematics and Computer Science, Northwest Minzu University, Lanzhou, Gansu, China.
- Key Laboratory of China's Ethnic Languages and Information Technology of Ministry of Education, Northwest Minzu University, Lanzhou, Gansu, China. [email protected].
- School of Mathematics and Computer Science, Northwest Minzu University, Lanzhou, Gansu, China. [email protected].
- Gansu Provincial Engineering Research Center of Multimodal Artificial Intelligence, Northwest Minzu University, Lanzhou, Gansu, China. [email protected].
- Gansu Provincial Engineering Research Center of Multimodal Artificial Intelligence, Northwest Minzu University, Lanzhou, Gansu, China.
- Department of Nuclear Medicine, Gansu Provincial Cancer Hospital, Lanzhou, Gansu, China.
- School of Computing, Mathematics and Engineering, Charles Sturt University, Albury, NSW, Australia.
Abstract
Single-photon emission computed tomography (SPECT) plays a crucial role in detecting bone metastases from lung cancer. However, its low spatial resolution and lesion similarity to benign structures present significant challenges for accurate segmentation, especially for lesions of varying sizes. We propose a deep learning-based segmentation framework that integrates conditional adversarial learning with a multi-scale feature extraction generator. The generator employs cascade dilated convolutions, multi-scale modules, and deep supervision, while the discriminator utilizes multi-scale L1 loss computed on image-mask pairs to guide segmentation learning. The proposed model was evaluated on a dataset of 286 clinically annotated SPECT scintigrams. It achieved a Dice Similarity Coefficient (DSC) of 0.6671, precision of 0.7228, and recall of 0.6196 - outperforming both classical and recent adversarial segmentation models in multi-scale lesion detection, especially for small and clustered lesions. Our results demonstrate that the integration of multi-scale feature learning with adversarial supervision significantly improves the segmentation of bone metastasis in SPECT imaging. This approach shows potential for clinical decision support in the management of lung cancer.