Deep Learning Model for Real-Time Nuchal Translucency Assessment at Prenatal US.
Authors
Affiliations (7)
Affiliations (7)
- National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Health Science Center, Shenzhen University, No. 3688 Nanhai Avenue, Nanshan District, Shenzhen 518060, PR China.
- Medical Ultrasound Image Computing (MUSIC) Lab, Shenzhen University, Shenzhen, PR China.
- Marshall Laboratory of Biomedical Engineering, Shenzhen University, Shenzhen, PR China.
- Center for Medical Ultrasound, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, PR China.
- Shenzhen RayShape Medical Technology Co, Ltd, Shenzhen, PR China.
- Department of Computer Science and Engineering, Southern University of Science and Technology, Shenzhen, PR China.
- Department of Medical Ultrasonics, First People's Hospital of Foshan, Foshan, PR China.
Abstract
Purpose To develop and evaluate an artificial intelligence-based model for real-time nuchal translucency (NT) plane identification and measurement in prenatal US assessments. Materials and Methods In this retrospective multicenter study conducted from January 2022 to October 2023, the Automated Identification and Measurement of NT (AIM-NT) model was developed and evaluated using internal and external datasets. NT plane assessment, including identification of the NT plane and measurement of NT thickness, was independently conducted by AIM-NT and experienced radiologists, with the results subsequently audited by radiology specialists and accuracy compared between groups. To assess alignment of artificial intelligence with radiologist workflow, discrepancies between the AIM-NT model and radiologists in NT plane identification time and thickness measurements were evaluated. Results The internal dataset included a total of 3959 NT images from 3153 fetuses, and the external dataset included 267 US videos from 267 fetuses. On the internal testing dataset, AIM-NT achieved an area under the receiver operating characteristic curve of 0.92 for NT plane identification. On the external testing dataset, there was no evidence of differences between AIM-NT and radiologists in NT plane identification accuracy (88.8% vs 87.6%, <i>P</i> = .69) or NT thickness measurements on standard and nonstandard NT planes (<i>P</i> = .29 and .59). AIM-NT demonstrated high consistency with radiologists in NT plane identification time, with 1-minute discrepancies observed in 77.9% of cases, and NT thickness measurements, with a mean difference of 0.03 mm and mean absolute error of 0.22 mm (95% CI: 0.19, 0.25). Conclusion AIM-NT demonstrated high accuracy in identifying the NT plane and measuring NT thickness on prenatal US images, showing minimal discrepancies with radiologist workflow. <b>Keywords:</b> Ultrasound, Fetus, Segmentation, Feature Detection, Diagnosis, Convolutional Neural Network (CNN) <i>Supplemental material is available for this article.</i> © RSNA, 2025 See also commentary by Horii in this issue.