Delineating retinal breaks in ultra-widefield fundus images with a PraNet-based machine learning model

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Abstract

BackgroundRetinal breaks are critical lesions that can lead to retinal detachment and vision loss if not detected and treated early. Automated and precise delineation of retinal breaks using ultra- widefield fundus (UWF) images remain a significant challenge in ophthalmology. ObjectiveThis study aimed to develop and validate a deep learning model based on the PraNet architecture for the accurate delineation of retinal breaks in UWF images, with a particular focus on segmentation performance in retinal break-positive cases. MethodsWe developed a deep learning segmentation model based on the PraNet architecture. This study utilized a dataset consisting of 8,083 cases and a total of 34,867 UWF images. Of these, 960 images contained retinal breaks, while the remaining 33,907 images did not. The dataset was split into 34,713 images for training, 81 for validation, and 73 for testing. The model was trained and validated on this dataset. Model performance was evaluated using both image-wise segmentation metrics (accuracy, precision, recall, Intersection over Union (IoU), dice score, centroid distance score) and lesion-wise detection metrics (sensitivity, positive predictive value). ResultsThe PraNet-based model achieved an accuracy of 0.996, a precision of 0.635, a recall of 0.756, an IoU of 0.539, a dice score of 0.652, and a centroid distance score of 0.081 for pixel-level detection of retinal breaks. The lesion-wise sensitivity was calculated as 0.885, and the positive predictive value (PPV) was 0.742. ConclusionsTo our knowledge, this is the first study to present pixel-level localization of retinal breaks using deep learning on UWF images. Our findings demonstrate that the PraNet-based model provides precise and robust pixel-level segmentation of retinal breaks in UWF images. This approach offers a clinically applicable tool for the precise delineation of retinal breaks, with the potential to improve patient outcomes. Future work should focus on external validation across multiple institutions and integration of additional annotation strategies to further enhance model performance and generalizability.

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