Three-dimensional automated segmentation of adolescent idiopathic scoliosis on computed tomography driven by deep learning: A retrospective study.
Authors
Affiliations (3)
Affiliations (3)
- Department of Spine II, The Ninth Medical Center, Chinese PLA General Hospital, Beijing, China.
- College of Automation, Hangzhou Dianzi University, Hangzhou, Zhejiang, China.
- Department of Biomedical Engineering, University of Houston, Houston, TX.
Abstract
Accurate vertebrae segmentation is crucial for modern surgical technologies, and deep learning networks provide valuable tools for this task. This study explores the application of advanced deep learning-based methods for segmenting vertebrae in computed tomography (CT) images of adolescent idiopathic scoliosis (AIS) patients. In this study, we collected a dataset of 31 samples from AIS patients, covering a wide range of spinal regions from cervical to lumbar vertebrae. High-resolution CT images were obtained for each sample, forming the basis of our segmentation analysis. We utilized 2 popular neural networks, U-Net and Attention U-Net, to segment the vertebrae in these CT images. Segmentation performance was rigorously evaluated using 2 key metrics: the Dice Coefficient Score to measure overlap between segmented and ground truth regions, and the Hausdorff distance (HD) to assess boundary dissimilarity. Both networks performed well, with U-Net achieving an average Dice coefficient of 92.2 ± 2.4% and an HD of 9.80 ± 1.34 mm. Attention U-Net showed similar results, with a Dice coefficient of 92.3 ± 2.9% and an HD of 8.67 ± 3.38 mm. When applied to the challenging anatomy of AIS, our findings align with literature results from advanced 3D U-Nets on healthy spines. Although no significant overall difference was observed between the 2 networks (P > .05), Attention U-Net exhibited an improved Dice coefficient (91.5 ± 0.0% vs 88.8 ± 0.1%, P = .151) and a significantly better HD (9.04 ± 4.51 vs. 13.60 ± 2.26 mm, P = .027) in critical scoliosis sites (mid-thoracic region), suggesting enhanced suitability for complex anatomy. Our study indicates that U-Net neural networks are feasible and effective for automated vertebrae segmentation in AIS patients using clinical 3D CT images. Attention U-Net demonstrated improved performance in thoracic levels, which are primary sites of scoliosis and may be more suitable for challenging anatomical regions.