Late gadolinium enhancement imaging and sudden cardiac death.
Authors
Prasad SK,Akbari T,Bishop MJ,Halliday BP,Leyva-Leon F,Marchlinski F
Affiliations (5)
Affiliations (5)
- Royal Brompton and Harefield Hospitals, Part of Guy's and St Thomas' NHS Foundation Trust, CMR Unit, Sydney Street, London SW3 6NP, UK.
- Imperial College London, National Heart and Lung Institute, Guy Scadding Building, Cale Street, London SW3 6LY, UK.
- School of Biomedical Engineering and Imaging Sciences, King's College London, Lambeth Wing St. Thomas' Hospital, Westminster Bridge Road, London SE1 7EH, UK.
- Aston Medical School, Translational Medicine Research Group (TMRG) College of Health and Life Sciences, Aston University, Birmingham B4 7ET, UK.
- Penn Heart and Vascular Center, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Abstract
The prediction and management of sudden cardiac death risk continue to pose significant challenges in cardiovascular care despite advances in therapies over the last two decades. Late gadolinium enhancement (LGE) on cardiac magnetic resonance-a marker of myocardial fibrosis-is a powerful non-invasive tool with the potential to aid the prediction of sudden death and direct the use of preventative therapies in several cardiovascular conditions. In this state-of-the-art review, we provide a critical appraisal of the current evidence base underpinning the utility of LGE in both ischaemic and non-ischaemic cardiomyopathies together with a focus on future perspectives and the role for machine learning and digital twin technologies.
Topics
Journal Article