Artificial Intelligence Chest CT Imaging for the Diagnosis of Tuberculosis-Destroyed Lung with PH.
Authors
Affiliations (4)
Affiliations (4)
- Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Jianghan University, No.168 Hongkong Road, Wuhan 430000, Hubei, China.
- National Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, No 2, East Yinghua Road, Beijing 100029, China.
- Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Jianghan University, No.168 Hongkong Road, Wuhan 430000, Hubei, China. Electronic address: [email protected].
- Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Jianghan University, No.168 Hongkong Road, Wuhan 430000, Hubei, China. Electronic address: [email protected].
Abstract
Explore the clinical characteristics of Tuberculosis Destroyed Lung (TDL) with pulmonary hypertension. Use Artificial Intelligence (AI) CT Imaging for the Diagnosis of TDL Patients with PH. 51 cases of TDL patients. Based on the results of the right heart catheterization examination, the patients were divided into two groups: TDL with group (n=31) and TDL Non-PH (n=20). The original chest CT data of the patients were reconstructed, segmented, and rendered using AI, and lung volume-related data were calculated. The differences in clinical data, hemodynamic data, and lung volume-related data between the two groups of patients were compared. The proportion of TDL patients with PH is significantly higher than those without TDL (61.82% vs. 22.64%, P<0.01). There were significant differences between the two groups of patients in terms of pulmonary function, PCWP/PVR, PASP/TRV and total volume of destroyed lung tissue (V<sub>TDLT</sub>) (P<0.05), and V<sub>TDLT</sub> is positively correlated with mean pulmonary arterial pressure (mPAP). Combined Diagnosis (V<sub>TDLT</sub> + PSAP): The area under the AUC was 0.917 (95%CI: 0.802-1), with a predicted probability of 0.51 and a Youden index of 0.789. The sensitivity was 90% and specificity was 88.9%. Patients with TDL accompanied by pulmonary hypertension are related to restrictive disorders. The V<sub>TDLT</sub> is positively correlated with mPAP. By calculating the V<sub>TDLT</sub> and combining it with the estimated PASP from echocardiography, it assists in the diagnosis of PH in these patients.