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Toward Digital Twins for Optimal Radioembolization.

Authors

Panneerselvam NK,Mummaneni G,Roncali E

Affiliations (2)

  • Department of Biomedical Engineering, University of California Davis, Davis, CA, USA.
  • Department of Biomedical Engineering, University of California Davis, Davis, CA, USA; Department of Radiology, University of California Davis Health, Sacramento, CA, USA. Electronic address: [email protected].

Abstract

Radioembolization is a liver cancer treatment delivering radioactive microspheres (20-60 μm) to tumors via a catheter in the hepatic arterial tree. Treatment response depends on multiple factors including the complex hepatic artery anatomy, variable blood flow, and microsphere transport. Patient-specific digital twins powered by computational fluid dynamics (CFD) and physics-informed artificial intelligence (AI) methods offer a promising solution to optimize planning. This review discusses core principles of CFD and generative AI applied to radioembolization, emphasizing physics-informed networks and their role in translating digital twins into clinical practice for enhanced personalization and precision in treatment delivery.

Topics

Journal ArticleReview

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