Application of Deep Learning for Predicting Hematoma Expansion in Intracerebral Hemorrhage Using Computed Tomography Scans: A Systematic Review and Meta-Analysis of Diagnostic Accuracy.
Authors
Affiliations (6)
Affiliations (6)
- Department of Radiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
- Guilan University of Medical Sciences, Rasht, Iran.
- DiCIPHR (Diffusion and Connectomics in Precision Healthcare Research) Lab, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
- Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
- Department of Radiology, Mayo Clinic, Rochester, MN, USA.
- Department of Radiology and Biomedical Imaging, Yale School of Medicine, 20 York St, New Haven, CT, 06510, USA. [email protected].
Abstract
We aimed to systematically review the studies that utilized deep learning (DL)-based networks to predict hematoma expansion (HE) in patients with intracerebral hemorrhage (ICH) using computed tomography (CT) images. We carried out a comprehensive literature search across four major databases to identify relevant studies. To evaluate the quality of the included studies, we used both the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) and the METhodological RadiomICs Score (METRICS) checklists. We then calculated pooled diagnostic estimates and assessed heterogeneity using the I<sup>2</sup> statistic. To assess the sources of heterogeneity, effects of individual studies, and publication bias, we performed subgroup analysis, sensitivity analysis, and Deek's asymmetry test. Twenty-two studies were included in the qualitative synthesis, of which 11 and 6 were utilized for exclusive DL and combined DL meta-analyses, respectively. We found pooled sensitivity of 0.81 and 0.84, specificity of 0.79 and 0.91, positive diagnostic likelihood ratio (DLR) of 3.96 and 9.40, negative DLR of 0.23 and 0.18, diagnostic odds ratio of 16.97 and 53.51, and area under the curve of 0.87 and 0.89 for exclusive DL-based and combined DL-based models, respectively. Subgroup analysis revealed significant inter-group differences according to the segmentation technique and study quality. DL-based networks showed strong potential in accurately identifying HE in ICH patients. These models may guide earlier targeted interventions such as intensive blood pressure control or administration of hemostatic drugs, potentially leading to improved patient outcomes.