Deep learning-based assessment of paraspinal muscle degeneration and its relationships to muscle function and disability outcomes in chronic low back pain: a prospective study.
Authors
Affiliations (9)
Affiliations (9)
- 7T Magnetic Resonance Translational Medicine Research Center, Department of Radiology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
- School of Mechanical and Electrical Engineering, University of Electronic Science and Technology of China, Chengdu, China.
- Department of Rehabilitation, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
- Department of Orthopedics, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
- Department of Orthopedics, The 958th Hospital of the People's Liberation Army, Chongqing, China.
- MR Research Collaboration Team, Siemens Healthineers Ltd, Guangzhou, China.
- 7T Magnetic Resonance Translational Medicine Research Center, Department of Radiology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China. [email protected].
- School of Mechanical and Electrical Engineering, University of Electronic Science and Technology of China, Chengdu, China. [email protected].
- 7T Magnetic Resonance Translational Medicine Research Center, Department of Radiology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China. [email protected].
Abstract
To investigate deep-learning (DL) model accuracy in quantifying multifidus (MF) and erector spinae (ES) fat fraction (FF) compared to Dixon MRI, and to explore the indirect effect of muscle function between muscle degeneration and disability outcomes in chronic low back pain (CLBP). 96 CLBP and 86 healthy participants underwent 3 T MRI, muscle function assessment, Oswestry Disability Index (ODI), Roland-Morris Disability Questionnaire (RMDQ), and Short Form 36-Health Survey (SF-36). A DL-Otsu thresholding model quantified muscle FF and functional muscle volume from 3D T2_WI images, validated against Dixon-FF. Lin's concordance correlation coefficient (CCC), Bland-Altman, and Passing-Bablok analyses assessed the concordance between Otsu-FF and Dixon-FF. Partial correlations and mediation analysis examined associations among muscle degeneration, muscle function, and disability outcomes. Otsu-FF showed agreement with Dixon-FF (MF: CCC = 0.96, 95% CI: 0.95, 0.97; ES: CCC = 0.95, 95% CI: 0.94, 0.96; bias: MF = 0.009; ES = 0.021). Partial correlations revealed MF and ES FF correlated with disability scores (ODI/RMDQ: r = 0.25 to 0.49; SF-36: r = -0.42, -0.28, p < 0.01). Muscle endurance negatively correlated with ODI (r = -0.57, 95% CI: -0.65, -0.45) and RMDQ (r = -0.49, 95% CI: -0.61, -0.35), positively with SF-36 (r = 0.51, 95% CI: 0.38, 0.63) (p < 0.01). Muscle endurance showed indirect effects on associations between muscle FF and disability outcomes (mediation proportion: 27.12% to 100%). DL method accurately quantified muscle FF, closely matching Dixon results. Muscle FF correlated with disability outcomes in CLBP, with muscle endurance demonstrating a statistically indirect association within this relationship. Question What are the associations between the deep learning-derived paraspinal muscle degeneration index, muscle function, and lumbar disability outcomes among patients with chronic low back pain? Findings In chronic low back pain, deep learning-quantified higher fat fraction of paraspinal muscles correlated with worse lumbar disability outcomes, with muscle endurance demonstrating an indirect effect in this association. Clinical relevance Incorporating the fat fraction of multifidus and erector spinae muscles and muscle endurance assessment is helpful for targeting rehabilitation training in chronic low back pain, improving disability outcomes.