Feasibility and accuracy of the fully automated three-dimensional echocardiography right ventricular quantification software in children: validation against cardiac magnetic resonance.
Authors
Affiliations (13)
Affiliations (13)
- Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Clinical Research Center for Medical Imaging in Hubei Province, Hubei Province Key Laboratory of Molecular Imaging, 1277 Jiefang Avenue, Wuhan, 430022, China.
- Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, China.
- Department of Ultrasound, Wuhan No.1 Hospital, Wuhan, China.
- Clinical Research Center for Medical Imaging in Hubei Province, Wuhan, China.
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China.
- Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
- Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, China. [email protected].
- Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Clinical Research Center for Medical Imaging in Hubei Province, Hubei Province Key Laboratory of Molecular Imaging, 1277 Jiefang Avenue, Wuhan, 430022, China. [email protected].
- Clinical Research Center for Medical Imaging in Hubei Province, Wuhan, China. [email protected].
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China. [email protected].
- Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Clinical Research Center for Medical Imaging in Hubei Province, Hubei Province Key Laboratory of Molecular Imaging, 1277 Jiefang Avenue, Wuhan, 430022, China. [email protected].
- Clinical Research Center for Medical Imaging in Hubei Province, Wuhan, China. [email protected].
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China. [email protected].
Abstract
Previous studies have confirmed that fully automated three-dimensional echocardiography (3DE) right ventricular (RV) quantification software can accurately assess adult RV function. However, data on its accuracy in children are scarce. This study aimed to test the accuracy of the software in children using cardiac magnetic resonance (MR) as the gold standard. This study prospectively enrolled 82 children who underwent both echocardiography and cardiac MR within 24 h. The RV end-diastolic volume (EDV), end-systolic volume (ESV), and ejection fraction (EF) were obtained using the novel 3DE-RV quantification software and compared with cardiac MR values across different groups. The novel 3DE-RV quantification software was feasible in all 82 children (100%). Fully automated analysis was achieved in 35% patients with an analysis time of 8 ± 2 s and 100% reproducibility. Manual editing was necessary in the remaining 65% patients. The 3DE-derived RV volumes and EF correlated well with cardiac MR measurements (RVEDV, r=0.93; RVESV, r=0.90; RVEF, r=0.82; all P <0.001). Although the automated approach slightly underestimated RV volumes and overestimated RVEF compared with cardiac MR in the entire cohort, the bias was smaller in children with RVEF ≥ 45%, normal RV size, and good 3DE image quality. Fully automated 3DE-RV quantification software provided accurate and completely reproducible results in 35% children without any adjustment. The RV volumes and EF measured using the automated 3DE method correlated well with those from cardiac MR, especially in children with RVEF ≥ 45%, normal RV size, and good 3DE image quality. Therefore, the novel automated 3DE method may achieve rapid and accurate assessment of RV function in children with normal heart anatomy.