Most machine learning-based image segmentation models produce pixel-wise confidence scores - typically derived from softmax outputs - that represent the model's predicted probability for each class label at every pixel. While this information can be particularly valuable in high-stakes domains such as medical imaging, these (uncalibrated) scores are heuristic in nature and do not constitute rigorous quantitative uncertainty estimates. Conformal prediction (CP) provides a principled framework for transforming heuristic confidence scores into statistically valid uncertainty estimates. However, applying CP directly to image segmentation ignores the spatial correlations between pixels, a fundamental characteristic of image data. This can result in overly conservative and less interpretable uncertainty estimates. To address this, we propose CONSIGN (Conformal Segmentation Informed by Spatial Groupings via Decomposition), a CP-based method that incorporates spatial correlations to improve uncertainty quantification in image segmentation. Our method generates meaningful prediction sets that come with user-specified, high-probability error guarantees. It is compatible with any pre-trained segmentation model capable of generating multiple sample outputs - such as those using dropout, Bayesian modeling, or ensembles. We evaluate CONSIGN against a standard pixel-wise CP approach across three medical imaging datasets and two COCO dataset subsets, using three different pre-trained segmentation models. Results demonstrate that accounting for spatial structure significantly improves performance across multiple metrics and enhances the quality of uncertainty estimates.

A common neurodegenerative disease, Alzheimer's disease requires a precise diagnosis and efficient treatment, particularly in light of escalating healthcare expenses and the expanding use of artificial intelligence in medical diagnostics. Many recent studies shows that the combination of brain Magnetic Resonance Imaging (MRI) and deep neural networks have achieved promising results for diagnosing AD. Using deep convolutional neural networks, this paper introduces a novel deep learning architecture that incorporates multiresidual blocks, specialized spatial attention blocks, grouped query attention, and multi-head attention. The study assessed the model's performance on four publicly accessible datasets and concentrated on identifying binary and multiclass issues across various categories. This paper also takes into account of the explainability of AD's progression and compared with state-of-the-art methods namely Gradient Class Activation Mapping (GradCAM), Score-CAM, Faster Score-CAM, and XGRADCAM. Our methodology consistently outperforms current approaches, achieving 99.66\% accuracy in 4-class classification, 99.63\% in 3-class classification, and 100\% in binary classification using Kaggle datasets. For Open Access Series of Imaging Studies (OASIS) datasets the accuracies are 99.92\%, 99.90\%, and 99.95\% respectively. The Alzheimer's Disease Neuroimaging Initiative-1 (ADNI-1) dataset was used for experiments in three planes (axial, sagittal, and coronal) and a combination of all planes. The study achieved accuracies of 99.08\% for axis, 99.85\% for sagittal, 99.5\% for coronal, and 99.17\% for all axis, and 97.79\% and 8.60\% respectively for ADNI-2. The network's ability to retrieve important information from MRI images is demonstrated by its excellent accuracy in categorizing AD stages.

The International Society of Ultrasound advocates Intrapartum Ultrasound (US) Imaging in Obstetrics and Gynecology (ISUOG) to monitor labour progression through changes in fetal head position. Two reliable ultrasound-derived parameters that are used to predict outcomes of instrumental vaginal delivery are the angle of progression (AoP) and head-symphysis distance (HSD). In this work, as part of the Intrapartum Ultrasounds Grand Challenge (IUGC) 2024, we propose an automated fetal biometry measurement pipeline to reduce intra- and inter-observer variability and improve measurement reliability. Our pipeline consists of three key tasks: (i) classification of standard planes (SP) from US videos, (ii) segmentation of fetal head and pubic symphysis from the detected SPs, and (iii) computation of the AoP and HSD from the segmented regions. We perform sparse sampling to mitigate class imbalances and reduce spurious correlations in task (i), and utilize ensemble-based deep learning methods for task (i) and (ii) to enhance generalizability under different US acquisition settings. Finally, to promote robustness in task iii) with respect to the structural fidelity of measurements, we retain the largest connected components and apply ellipse fitting to the segmentations. Our solution achieved ACC: 0.9452, F1: 0.9225, AUC: 0.983, MCC: 0.8361, DSC: 0.918, HD: 19.73, ASD: 5.71, $\Delta_{AoP}$: 8.90 and $\Delta_{HSD}$: 14.35 across an unseen hold-out set of 4 patients and 224 US frames. The results from the proposed automated pipeline can improve the understanding of labour arrest causes and guide the development of clinical risk stratification tools for efficient and effective prenatal care.

Ultrasound imaging is widely applied in clinical practice, yet ultrasound videos often suffer from low signal-to-noise ratios (SNR) and limited resolutions, posing challenges for diagnosis and analysis. Variations in equipment and acquisition settings can further exacerbate differences in data distribution and noise levels, reducing the generalizability of pre-trained models. This work presents a self-supervised ultrasound video super-resolution algorithm called Deep Ultrasound Prior (DUP). DUP employs a video-adaptive optimization process of a neural network that enhances the resolution of given ultrasound videos without requiring paired training data while simultaneously removing noise. Quantitative and visual evaluations demonstrate that DUP outperforms existing super-resolution algorithms, leading to substantial improvements for downstream applications.

Brain-to-image decoding has been recently propelled by the progress in generative AI models and the availability of large ultra-high field functional Magnetic Resonance Imaging (fMRI). However, current approaches depend on complicated multi-stage pipelines and preprocessing steps that typically collapse the temporal dimension of brain recordings, thereby limiting time-resolved brain decoders. Here, we introduce Dynadiff (Dynamic Neural Activity Diffusion for Image Reconstruction), a new single-stage diffusion model designed for reconstructing images from dynamically evolving fMRI recordings. Our approach offers three main contributions. First, Dynadiff simplifies training as compared to existing approaches. Second, our model outperforms state-of-the-art models on time-resolved fMRI signals, especially on high-level semantic image reconstruction metrics, while remaining competitive on preprocessed fMRI data that collapse time. Third, this approach allows a precise characterization of the evolution of image representations in brain activity. Overall, this work lays the foundation for time-resolved brain-to-image decoding.

Semi-supervised learning (SSL) has achieved significant progress in medical image segmentation (SSMIS) through effective utilization of limited labeled data. While current SSL methods for medical images predominantly rely on consistency regularization and pseudo-labeling, they often overlook transferable semantic relationships across different clinical domains and imaging modalities. To address this, we propose TransMedSeg, a novel transferable semantic framework for semi-supervised medical image segmentation. Our approach introduces a Transferable Semantic Augmentation (TSA) module, which implicitly enhances feature representations by aligning domain-invariant semantics through cross-domain distribution matching and intra-domain structural preservation. Specifically, TransMedSeg constructs a unified feature space where teacher network features are adaptively augmented towards student network semantics via a lightweight memory module, enabling implicit semantic transformation without explicit data generation. Interestingly, this augmentation is implicitly realized through an expected transferable cross-entropy loss computed over the augmented teacher distribution. An upper bound of the expected loss is theoretically derived and minimized during training, incurring negligible computational overhead. Extensive experiments on medical image datasets demonstrate that TransMedSeg outperforms existing semi-supervised methods, establishing a new direction for transferable representation learning in medical image analysis.

Medical image captioning is a challenging task that requires generating clinically accurate and semantically meaningful descriptions of radiology images. While recent vision-language models (VLMs) such as BLIP, BLIP2, Gemini and ViT-GPT2 show strong performance on natural image datasets, they often produce generic or imprecise captions when applied to specialized medical domains. In this project, we explore the effectiveness of fine-tuning the BLIP model on the ROCO dataset for improved radiology captioning. We compare the fine-tuned BLIP against its zero-shot version, BLIP-2 base, BLIP-2 Instruct and a ViT-GPT2 transformer baseline. Our results demonstrate that domain-specific fine-tuning on BLIP significantly improves performance across both quantitative and qualitative evaluation metrics. We also visualize decoder cross-attention maps to assess interpretability and conduct an ablation study to evaluate the contributions of encoder-only and decoder-only fine-tuning. Our findings highlight the importance of targeted adaptation for medical applications and suggest that decoder-only fine-tuning (encoder-frozen) offers a strong performance baseline with 5% lower training time than full fine-tuning, while full model fine-tuning still yields the best results overall.

Large language models (LLMs) have demonstrated remarkable capabilities in various domains, including radiology report generation. Previous approaches have attempted to utilize multimodal LLMs for this task, enhancing their performance through the integration of domain-specific knowledge retrieval. However, these approaches often overlook the knowledge already embedded within the LLMs, leading to redundant information integration and inefficient utilization of learned representations. To address this limitation, we propose RADAR, a framework for enhancing radiology report generation with supplementary knowledge injection. RADAR improves report generation by systematically leveraging both the internal knowledge of an LLM and externally retrieved information. Specifically, it first extracts the model's acquired knowledge that aligns with expert image-based classification outputs. It then retrieves relevant supplementary knowledge to further enrich this information. Finally, by aggregating both sources, RADAR generates more accurate and informative radiology reports. Extensive experiments on MIMIC-CXR, CheXpert-Plus, and IU X-ray demonstrate that our model outperforms state-of-the-art LLMs in both language quality and clinical accuracy

This study explores the use of Federated Learning (FL) for tuberculosis (TB) diagnosis using chest X-rays in low-resource settings across Africa. FL allows hospitals to collaboratively train AI models without sharing raw patient data, addressing privacy concerns and data scarcity that hinder traditional centralized models. The research involved hospitals and research centers in eight African countries. Most sites used local datasets, while Ghana and The Gambia used public ones. The study compared locally trained models with a federated model built across all institutions to evaluate FL's real-world feasibility. Despite its promise, implementing FL in sub-Saharan Africa faces challenges such as poor infrastructure, unreliable internet, limited digital literacy, and weak AI regulations. Some institutions were also reluctant to share model updates due to data control concerns. In conclusion, FL shows strong potential for enabling AI-driven healthcare in underserved regions, but broader adoption will require improvements in infrastructure, education, and regulatory support.

In many real-world applications, deployed models encounter inputs that differ from the data seen during training. Out-of-distribution detection identifies whether an input stems from an unseen distribution, while open-world recognition flags such inputs to ensure the system remains robust as ever-emerging, previously $unknown$ categories appear and must be addressed without retraining. Foundation and vision-language models are pre-trained on large and diverse datasets with the expectation of broad generalization across domains, including medical imaging. However, benchmarking these models on test sets with only a few common outlier types silently collapses the evaluation back to a closed-set problem, masking failures on rare or truly novel conditions encountered in clinical use. We therefore present $NOVA$, a challenging, real-life $evaluation-only$ benchmark of $\sim$900 brain MRI scans that span 281 rare pathologies and heterogeneous acquisition protocols. Each case includes rich clinical narratives and double-blinded expert bounding-box annotations. Together, these enable joint assessment of anomaly localisation, visual captioning, and diagnostic reasoning. Because NOVA is never used for training, it serves as an $extreme$ stress-test of out-of-distribution generalisation: models must bridge a distribution gap both in sample appearance and in semantic space. Baseline results with leading vision-language models (GPT-4o, Gemini 2.0 Flash, and Qwen2.5-VL-72B) reveal substantial performance drops across all tasks, establishing NOVA as a rigorous testbed for advancing models that can detect, localize, and reason about truly unknown anomalies.