The accurate segmentation of myocardial scars from cardiac MRI is essential for clinical assessment and treatment planning. In this study, we propose a robust deep-learning pipeline for fully automated myocardial scar detection and segmentation by fine-tuning state-of-the-art models. The method explicitly addresses challenges of label noise from semi-automatic annotations, data heterogeneity, and class imbalance through the use of Kullback-Leibler loss and extensive data augmentation. We evaluate the model's performance on both acute and chronic cases and demonstrate its ability to produce accurate and smooth segmentations despite noisy labels. In particular, our approach outperforms state-of-the-art models like nnU-Net and shows strong generalizability in an out-of-distribution test set, highlighting its robustness across various imaging conditions and clinical tasks. These results establish a reliable foundation for automated myocardial scar quantification and support the broader clinical adoption of deep learning in cardiac imaging.

Solving Electromagnetic Inverse Scattering Problems (EISP) is fundamental in applications such as medical imaging, where the goal is to reconstruct the relative permittivity from scattered electromagnetic field. This inverse process is inherently ill-posed and highly nonlinear, making it particularly challenging. A recent machine learning-based approach, Img-Interiors, shows promising results by leveraging continuous implicit functions. However, it requires case-specific optimization, lacks generalization to unseen data, and fails under sparse transmitter setups (e.g., with only one transmitter). To address these limitations, we revisit EISP from a physics-informed perspective, reformulating it as a two stage inverse transmission-scattering process. This formulation reveals the induced current as a generalizable intermediate representation, effectively decoupling the nonlinear scattering process from the ill-posed inverse problem. Built on this insight, we propose the first generalizable physics-driven framework for EISP, comprising a current estimator and a permittivity solver, working in an end-to-end manner. The current estimator explicitly learns the induced current as a physical bridge between the incident and scattered field, while the permittivity solver computes the relative permittivity directly from the estimated induced current. This design enables data-driven training and generalizable feed-forward prediction of relative permittivity on unseen data while maintaining strong robustness to transmitter sparsity. Extensive experiments show that our method outperforms state-of-the-art approaches in reconstruction accuracy, generalization, and robustness. This work offers a fundamentally new perspective on electromagnetic inverse scattering and represents a major step toward cost-effective practical solutions for electromagnetic imaging.

Precise aneurysm volume measurement offers a transformative edge for risk assessment and treatment planning in clinical settings. Currently, clinical assessments rely heavily on manual review of medical imaging, a process that is time-consuming and prone to inter-observer variability. The widely accepted standard-of-care primarily focuses on measuring aneurysm diameter at its widest point, providing a limited perspective on aneurysm morphology and lacking efficient methods to measure aneurysm volumes. Yet, volume measurement can offer deeper insight into aneurysm progression and severity. In this study, we propose an automated approach that leverages the strengths of pre-trained neural networks and expert systems to delineate aneurysm boundaries and compute volumes on an unannotated dataset from 60 patients. The dataset includes slice-level start/end annotations for aneurysm but no pixel-wise aorta segmentations. Our method utilizes a pre-trained UNet to automatically locate the aorta, employs SAM2 to track the aorta through vascular irregularities such as aneurysms down to the iliac bifurcation, and finally uses a Long Short-Term Memory (LSTM) network or expert system to identify the beginning and end points of the aneurysm within the aorta. Despite no manual aorta segmentation, our approach achieves promising accuracy, predicting the aneurysm start point with an R2 score of 71%, the end point with an R2 score of 76%, and the volume with an R2 score of 92%. This technique has the potential to facilitate large-scale aneurysm analysis and improve clinical decision-making by reducing dependence on annotated datasets.

In recent decades, the use of 4D Flow MRI images has enabled the quantification of velocity fields within a volume of interest and along the cardiac cycle. However, the lack of resolution and the presence of noise in these biomarkers are significant issues. As indicated by recent studies, it appears that biomarkers such as wall shear stress are particularly impacted by the poor resolution of vessel segmentation. The Phase Contrast Magnetic Resonance Angiography (PC-MRA) is the state-of-the-art method to facilitate segmentation. The objective of this work is to introduce a new handcraft feature that provides a novel visualisation of 4D Flow MRI images, which is useful in the segmentation task. This feature, termed Weighted Mean Frequencies (WMF), is capable of revealing the region in three dimensions where a voxel has been passed by pulsatile flow. Indeed, this feature is representative of the hull of all pulsatile velocity voxels. The value of the feature under discussion is illustrated by two experiments. The experiments involved segmenting 4D Flow MRI images using optimal thresholding and deep learning methods. The results obtained demonstrate a substantial enhancement in terms of IoU and Dice, with a respective increase of 0.12 and 0.13 in comparison with the PC-MRA feature, as evidenced by the deep learning task. This feature has the potential to yield valuable insights that could inform future segmentation processes in other vascular regions, such as the heart or the brain.

Periodontitis, a chronic inflammatory disease causing alveolar bone loss, significantly affects oral health and quality of life. Accurate assessment of bone loss severity and pattern is critical for diagnosis and treatment planning. In this study, we propose a novel AI-based deep learning framework to automatically detect and quantify alveolar bone loss and its patterns using intraoral periapical (IOPA) radiographs. Our method combines YOLOv8 for tooth detection with Keypoint R-CNN models to identify anatomical landmarks, enabling precise calculation of bone loss severity. Additionally, YOLOv8x-seg models segment bone levels and tooth masks to determine bone loss patterns (horizontal vs. angular) via geometric analysis. Evaluated on a large, expertly annotated dataset of 1000 radiographs, our approach achieved high accuracy in detecting bone loss severity (intra-class correlation coefficient up to 0.80) and bone loss pattern classification (accuracy 87%). This automated system offers a rapid, objective, and reproducible tool for periodontal assessment, reducing reliance on subjective manual evaluation. By integrating AI into dental radiographic analysis, our framework has the potential to improve early diagnosis and personalized treatment planning for periodontitis, ultimately enhancing patient care and clinical outcomes.

Vision Transformer has recently gained tremendous popularity in medical image segmentation task due to its superior capability in capturing long-range dependencies. However, transformer requires a large amount of labeled data to be effective, which hinders its applicability in annotation scarce semi-supervised learning scenario where only limited labeled data is available. State-of-the-art semi-supervised learning methods propose combinatorial CNN-Transformer learning to cross teach a transformer with a convolutional neural network, which achieves promising results. However, it remains a challenging task to effectively train the transformer with limited labeled data. In this paper, we propose an adversarial masked image modeling method to fully unleash the potential of transformer for semi-supervised medical image segmentation. The key challenge in semi-supervised learning with transformer lies in the lack of sufficient supervision signal. To this end, we propose to construct an auxiliary masked domain from original domain with masked image modeling and train the transformer to predict the entire segmentation mask with masked inputs to increase supervision signal. We leverage the original labels from labeled data and pseudo-labels from unlabeled data to learn the masked domain. To further benefit the original domain from masked domain, we provide a theoretical analysis of our method from a multi-domain learning perspective and devise a novel adversarial training loss to reduce the domain gap between the original and masked domain, which boosts semi-supervised learning performance. We also extend adversarial masked image modeling to CNN network. Extensive experiments on three public medical image segmentation datasets demonstrate the effectiveness of our method, where our method outperforms existing methods significantly. Our code is publicly available at https://github.com/zlheui/AdvMIM.

Text-to-image generative models have achieved remarkable breakthroughs in recent years. However, their application in medical image generation still faces significant challenges, including small dataset sizes, and scarcity of medical textual data. To address these challenges, we propose Med-Art, a framework specifically designed for medical image generation with limited data. Med-Art leverages vision-language models to generate visual descriptions of medical images which overcomes the scarcity of applicable medical textual data. Med-Art adapts a large-scale pre-trained text-to-image model, PixArt-$\alpha$, based on the Diffusion Transformer (DiT), achieving high performance under limited data. Furthermore, we propose an innovative Hybrid-Level Diffusion Fine-tuning (HLDF) method, which enables pixel-level losses, effectively addressing issues such as overly saturated colors. We achieve state-of-the-art performance on two medical image datasets, measured by FID, KID, and downstream classification performance.

Accurate gestational age (GA) estimation, ideally through fetal ultrasound measurement, is a crucial aspect of providing excellent antenatal care. However, deriving GA from manual fetal biometric measurements depends on the operator and is time-consuming. Hence, automatic computer-assisted methods are demanded in clinical practice. In this paper, we present a novel feature fusion framework to estimate GA using fetal ultrasound images without any measurement information. We adopt a deep learning model to extract deep representations from ultrasound images. We extract radiomic features to reveal patterns and characteristics of fetal brain growth. To harness the interpretability of radiomics in medical imaging analysis, we estimate GA by fusing radiomic features and deep representations. Our framework estimates GA with a mean absolute error of 8.0 days across three trimesters, outperforming current machine learning-based methods at these gestational ages. Experimental results demonstrate the robustness of our framework across different populations in diverse geographical regions. Our code is publicly available on \href{https://github.com/13204942/RadiomicsImageFusion_FetalUS}{GitHub}.

Hepatic echinococcosis (HE) is a widespread parasitic disease in underdeveloped pastoral areas with limited medical resources. While CNN-based and Transformer-based models have been widely applied to medical image segmentation, CNNs lack global context modeling due to local receptive fields, and Transformers, though capable of capturing long-range dependencies, are computationally expensive. Recently, state space models (SSMs), such as Mamba, have gained attention for their ability to model long sequences with linear complexity. In this paper, we propose EAGLE, a U-shaped network composed of a Progressive Visual State Space (PVSS) encoder and a Hybrid Visual State Space (HVSS) decoder that work collaboratively to achieve efficient and accurate segmentation of hepatic echinococcosis (HE) lesions. The proposed Convolutional Vision State Space Block (CVSSB) module is designed to fuse local and global features, while the Haar Wavelet Transformation Block (HWTB) module compresses spatial information into the channel dimension to enable lossless downsampling. Due to the lack of publicly available HE datasets, we collected CT slices from 260 patients at a local hospital. Experimental results show that EAGLE achieves state-of-the-art performance with a Dice Similarity Coefficient (DSC) of 89.76%, surpassing MSVM-UNet by 1.61%.

Osteoporosis, characterized by reduced bone mineral density (BMD) and compromised bone microstructure, increases fracture risk in aging populations. While dual-energy X-ray absorptiometry (DXA) is the clinical standard for BMD assessment, its limited accessibility hinders diagnosis in resource-limited regions. Opportunistic computed tomography (CT) analysis has emerged as a promising alternative for osteoporosis diagnosis using existing imaging data. Current approaches, however, face three limitations: (1) underutilization of unlabeled vertebral data, (2) systematic bias from device-specific DXA discrepancies, and (3) insufficient integration of clinical knowledge such as spatial BMD distribution patterns. To address these, we propose a unified deep learning framework with three innovations. First, a self-supervised learning method using radiomic representations to leverage unlabeled CT data and preserve bone texture. Second, a Mixture of Experts (MoE) architecture with learned gating mechanisms to enhance cross-device adaptability. Third, a multi-task learning framework integrating osteoporosis diagnosis, BMD regression, and vertebra location prediction. Validated across three clinical sites and an external hospital, our approach demonstrates superior generalizability and accuracy over existing methods for opportunistic osteoporosis screening and diagnosis.