We developed a pipeline for registering pre-surgery Magnetic Resonance (MR) images and post-resection Ultrasound (US) images. Our approach leverages unpaired style transfer using 3D CycleGAN to generate synthetic T1 images, thereby enhancing registration performance. Additionally, our registration process employs both affine and local deformable transformations for a coarse-to-fine registration. The results demonstrate that our approach improves the consistency between MR and US image pairs in most cases.

Medical image segmentation plays a crucial role in AI-assisted diagnostics, surgical planning, and treatment monitoring. Accurate and robust segmentation models are essential for enabling reliable, data-driven clinical decision making across diverse imaging modalities. Given the inherent variability in image characteristics across modalities, developing a unified model capable of generalizing effectively to multiple modalities would be highly beneficial. This model could streamline clinical workflows and reduce the need for modality-specific training. However, real-world deployment faces major challenges, including data scarcity, domain shift between modalities (e.g., CT vs. MRI), and privacy restrictions that prevent data sharing. To address these issues, we propose FedGIN, a Federated Learning (FL) framework that enables multimodal organ segmentation without sharing raw patient data. Our method integrates a lightweight Global Intensity Non-linear (GIN) augmentation module that harmonizes modality-specific intensity distributions during local training. We evaluated FedGIN using two types of datasets: an imputed dataset and a complete dataset. In the limited dataset scenario, the model was initially trained using only MRI data, and CT data was added to assess its performance improvements. In the complete dataset scenario, both MRI and CT data were fully utilized for training on all clients. In the limited-data scenario, FedGIN achieved a 12 to 18% improvement in 3D Dice scores on MRI test cases compared to FL without GIN and consistently outperformed local baselines. In the complete dataset scenario, FedGIN demonstrated near-centralized performance, with a 30% Dice score improvement over the MRI-only baseline and a 10% improvement over the CT-only baseline, highlighting its strong cross-modality generalization under privacy constraints.

Sex differences in mental health become more evident across adolescence, with a two-fold increase of prevalence of mood disorders in females compared to males. The brain underpinnings remain understudied. Here, we investigated the role of age, puberty and mental health in determining the longitudinal development of sex differences in brain structure. We captured sex differences in limbic and non-limbic structures using machine learning models trained in cross-sectional brain imaging data of 1132 youths, yielding limbic and non-limbic estimates of brain sex. Applied to two independent longitudinal samples (total: 8184 youths), our models revealed pronounced sex differences in brain structure with increasing age. For females, brain sex was sensitive to pubertal development (menarche) over time and, for limbic structures, to mood-related mental health. Our findings highlight the limbic system as a key contributor to the development of sex differences in the brain and the potential of machine learning models for brain sex classification to investigate sex-specific processes relevant to mental health.

Generative artificial intelligence (AI) is rapidly transforming medical imaging by enabling capabilities such as data synthesis, image enhancement, modality translation, and spatiotemporal modeling. This review presents a comprehensive and forward-looking synthesis of recent advances in generative modeling including generative adversarial networks (GANs), variational autoencoders (VAEs), diffusion models, and emerging multimodal foundation architectures and evaluates their expanding roles across the clinical imaging continuum. We systematically examine how generative AI contributes to key stages of the imaging workflow, from acquisition and reconstruction to cross-modality synthesis, diagnostic support, and treatment planning. Emphasis is placed on both retrospective and prospective clinical scenarios, where generative models help address longstanding challenges such as data scarcity, standardization, and integration across modalities. To promote rigorous benchmarking and translational readiness, we propose a three-tiered evaluation framework encompassing pixel-level fidelity, feature-level realism, and task-level clinical relevance. We also identify critical obstacles to real-world deployment, including generalization under domain shift, hallucination risk, data privacy concerns, and regulatory hurdles. Finally, we explore the convergence of generative AI with large-scale foundation models, highlighting how this synergy may enable the next generation of scalable, reliable, and clinically integrated imaging systems. By charting technical progress and translational pathways, this review aims to guide future research and foster interdisciplinary collaboration at the intersection of AI, medicine, and biomedical engineering.

Reconstructing high-fidelity MR images from undersampled k-space data remains a challenging problem in MRI. While Mamba variants for vision tasks offer promising long-range modeling capabilities with linear-time complexity, their direct application to MRI reconstruction inherits two key limitations: (1) insensitivity to high-frequency anatomical details; and (2) reliance on redundant multi-directional scanning. To address these limitations, we introduce High-Fidelity Mamba (HiFi-Mamba), a novel dual-stream Mamba-based architecture comprising stacked W-Laplacian (WL) and HiFi-Mamba blocks. Specifically, the WL block performs fidelity-preserving spectral decoupling, producing complementary low- and high-frequency streams. This separation enables the HiFi-Mamba block to focus on low-frequency structures, enhancing global feature modeling. Concurrently, the HiFi-Mamba block selectively integrates high-frequency features through adaptive state-space modulation, preserving comprehensive spectral details. To eliminate the scanning redundancy, the HiFi-Mamba block adopts a streamlined unidirectional traversal strategy that preserves long-range modeling capability with improved computational efficiency. Extensive experiments on standard MRI reconstruction benchmarks demonstrate that HiFi-Mamba consistently outperforms state-of-the-art CNN-based, Transformer-based, and other Mamba-based models in reconstruction accuracy while maintaining a compact and efficient model design.

Federated learning (FL) is a decentralized machine learning paradigm in which multiple clients collaboratively train a shared model without sharing their local private data. However, real-world applications of FL frequently encounter challenges arising from the non-identically and independently distributed (non-IID) local datasets across participating clients, which is particularly pronounced in the field of medical imaging, where shifts in image feature distributions significantly hinder the global model's convergence and performance. To address this challenge, we propose FedMP, a novel method designed to enhance FL under non-IID scenarios. FedMP employs stochastic feature manifold completion to enrich the training space of individual client classifiers, and leverages class-prototypes to guide the alignment of feature manifolds across clients within semantically consistent subspaces, facilitating the construction of more distinct decision boundaries. We validate the effectiveness of FedMP on multiple medical imaging datasets, including those with real-world multi-center distributions, as well as on a multi-domain natural image dataset. The experimental results demonstrate that FedMP outperforms existing FL algorithms. Additionally, we analyze the impact of manifold dimensionality, communication efficiency, and privacy implications of feature exposure in our method.

Brain tumor classification using MRI scans is crucial for early diagnosis and treatment planning. In this study, we first train a single Convolutional Neural Network (CNN) based on VGG16 [1], achieving a strong standalone test accuracy of 99.24% on a balanced dataset of 7,023 MRI images across four classes: glioma, meningioma, pituitary, and no tumor. To further improve classification performance, we implement three ensemble strategies: stacking, soft voting, and XGBoost-based ensembling [4], each trained on individually fine-tuned models. These ensemble methods significantly enhance prediction accuracy, with XGBoost achieving a perfect 100% accuracy, and voting reaching 99.54%. Evaluation metrics such as precision, recall, and F1-score confirm the robustness of the approach. This work demonstrates the power of combining fine-tuned deep learning models [5] for highly reliable brain tumor classification enhance prediction accuracy, with XGBoost achieving a perfect 100% accuracy, and voting reaching 99.54%. Evaluation metrics such as precision, recall, and F1-score confirm the robustness of the approach. This work demonstrates the power of combining fine-tuned deep learning models for highly reliable brain tumor classification.

Deploying deep learning models in clinical practice often requires leveraging multiple data modalities, such as images, text, and structured data, to achieve robust and trustworthy decisions. However, not all modalities are always available at inference time. In this work, we propose multimodal privileged knowledge distillation (MMPKD), a training strategy that utilizes additional modalities available solely during training to guide a unimodal vision model. Specifically, we used a text-based teacher model for chest radiographs (MIMIC-CXR) and a tabular metadata-based teacher model for mammography (CBIS-DDSM) to distill knowledge into a vision transformer student model. We show that MMPKD can improve the resulting attention maps' zero-shot capabilities of localizing ROI in input images, while this effect does not generalize across domains, as contrarily suggested by prior research.

This paper presents DDTracking, a novel deep generative framework for diffusion MRI tractography that formulates streamline propagation as a conditional denoising diffusion process. In DDTracking, we introduce a dual-pathway encoding network that jointly models local spatial encoding (capturing fine-scale structural details at each streamline point) and global temporal dependencies (ensuring long-range consistency across the entire streamline). Furthermore, we design a conditional diffusion model module, which leverages the learned local and global embeddings to predict streamline propagation orientations for tractography in an end-to-end trainable manner. We conduct a comprehensive evaluation across diverse, independently acquired dMRI datasets, including both synthetic and clinical data. Experiments on two well-established benchmarks with ground truth (ISMRM Challenge and TractoInferno) demonstrate that DDTracking largely outperforms current state-of-the-art tractography methods. Furthermore, our results highlight DDTracking's strong generalizability across heterogeneous datasets, spanning varying health conditions, age groups, imaging protocols, and scanner types. Collectively, DDTracking offers anatomically plausible and robust tractography, presenting a scalable, adaptable, and end-to-end learnable solution for broad dMRI applications. Code is available at: https://github.com/yishengpoxiao/DDtracking.git

Image registration is a fundamental technique in the analysis of longitudinal and multi-phase CT images within clinical practice. However, most existing methods are tailored for single-organ applications, limiting their generalizability to other anatomical regions. This work presents TotalRegistrator, an image registration framework capable of aligning multiple anatomical regions simultaneously using a standard UNet architecture and a novel field decomposition strategy. The model is lightweight, requiring only 11GB of GPU memory for training. To train and evaluate our method, we constructed a large-scale longitudinal dataset comprising 695 whole-body (thorax-abdomen-pelvic) paired CT scans from individual patients acquired at different time points. We benchmarked TotalRegistrator against a generic classical iterative algorithm and a recent foundation model for image registration. To further assess robustness and generalizability, we evaluated our model on three external datasets: the public thoracic and abdominal datasets from the Learn2Reg challenge, and a private multiphase abdominal dataset from a collaborating hospital. Experimental results on the in-house dataset show that the proposed approach generally surpasses baseline methods in multi-organ abdominal registration, with a slight drop in lung alignment performance. On out-of-distribution datasets, it achieved competitive results compared to leading single-organ models, despite not being fine-tuned for those tasks, demonstrating strong generalizability. The source code will be publicly available at: https://github.com/DIAGNijmegen/oncology_image_registration.git.