The study aimed at developing and validating a deep learning (DL) model based on the ultrasound imaging for predicting the platinum resistance of patients with epithelial ovarian cancer (EOC). 392 patients were enrolled in this retrospective study who had been diagnosed with EOC between 2014 and 2020 and underwent pelvic ultrasound before initial treatment. A DL model was developed to predict patients' platinum resistance, and the model underwent evaluation through receiver-operating characteristic (ROC) curves, decision curve analysis (DCA), and calibration curve. The ROC curves showed that the area under the curve (AUC) of the DL model for predicting patients' platinum resistance in the internal and external test sets were 0.86 (95% CI 0.83-0.90) and 0.86 (95% CI 0.84-0.89), respectively. The model demonstrated high clinical value through clinical decision curve analysis and exhibited good calibration efficiency in the training cohort. Kaplan-Meier analyses showed that the model's optimal cutoff value successfully distinguished between patients at high and low risk of recurrence, with hazard ratios of 3.1 (95% CI 2.3-4.1, P < 0.0001) and 2.9 (95% CI 2.3-3.9; P < 0.0001) in the high-risk group of the internal and external test sets, serving as a prognostic indicator. The DL model based on ultrasound imaging can predict platinum resistance in patients with EOC and may support clinicians in making the most appropriate treatment decisions.

Pneumonia is a major threat to the health of children, especially those under the age of five. Mycoplasma  pneumoniae infection is a core cause of pediatric pneumonia, and the incidence of severe mycoplasma pneumoniae pneumonia (SMPP) has increased in recent years. Therefore, there is an urgent need to establish an early warning model for SMPP to improve the prognosis of pediatric pneumonia. The study comprised 597 SMPP patients aged between 1 month and 18 years. Clinical data were selected through Lasso regression analysis, followed by the application of eight machine learning algorithms to develop early warning model. The accuracy of the model was assessed using validation and prospective cohort. To facilitate clinical assessment, the study simplified the indicators and constructed visualized simplified model. The clinical applicability of the model was evaluated by DCA and CIC curve. After variable selection, eight machine learning models were developed using age, sex and 21 serum indicators identified as predictive factors for SMPP. A Light Gradient Boosting Machine (LightGBM) model demonstrated strong performance, achieving AUC of 0.92 for prospective validation. The SHAP analysis was utilized to screen advantageous variables, which contains of serum S100A8/A9, tracheal computed tomography (CT), retinol-binding protein(RBP), platelet larger cell ratio(P-LCR) and CD4+CD25+Treg cell counts, for constructing a simplified model (SCRPT) to improve clinical applicability. The SCRPT diagnostic model exhibited favorable diagnostic efficacy (AUC > 0.8). Additionally, the study found that S100A8/A9 outperformed clinical inflammatory markers can also differentiate the severity of MPP. The SCRPT model consisting of five dominant variables (S100A8/A9, CT, RBP, PLCR and Treg cell) screened based on eight machine learning is expected to be a tool for early diagnosis of SMPP. S100A8/A9 can also be used as a biomarker for validity differentiation of SMPP when medical conditions are limited.

To evaluate the accuracy and reliability of a novel automated 3D CT-based method for measuring femoral neck anteversion (FNA) compared to three traditional manual methods. A total of 126 femurs from 63 full-length CT scans (35 men and 28 women; average age: 52.0 ± 14.7 years) were analyzed. The automated method used a deep learning network for femur segmentation, landmark identification, and anteversion calculation, with results generated based on two axes: Auto_GT (using the greater trochanter-to-intercondylar notch center axis) and Auto_P (using the piriformis fossa-to-intercondylar notch center axis). These results were validated through manual landmark annotation. The same dataset was assessed using three conventional manual methods: Murphy, Reikeras, and Lee methods. Intra- and inter-observer reliability were assessed using intraclass correlation coefficients (ICCs), and pairwise comparisons analyzed correlations and differences between methods. The automated methods produced consistent FNA measurements (Auto_GT: 17.59 ± 9.16° vs. Auto_P: 17.37 ± 9.17° on the right; 15.08 ± 9.88° vs. 14.84 ± 9.90° on the left). Intra-observer ICCs ranged from 0.864 to 0.961, and inter-observer ICCs between Auto_GT and the manual methods were high, except for the Lee method. No significant differences were observed between the two automated methods or between the automated and manual verification methods. Moreover, strong correlations (R > 0.9, p < 0.001) were found between Auto_GT and the manual methods. The novel automated 3D CT-based method demonstrates strong reproducibility and reliability for measuring femoral neck anteversion, with performance comparable to traditional manual techniques. These results indicate its potential utility for preoperative planning, postoperative evaluation, and computer-assisted orthopedic procedures. Not applicable.

Rapid technological advancements in noninvasive and invasive imaging including echocardiography, computed tomography, magnetic resonance imaging and positron emission tomography have allowed for improved anatomical visualization and precise measurement of cardiac structure and function. These imaging modalities allow for evaluation of how cardiac substrate changes, such as myocardial wall thickness, fibrosis, scarring and chamber enlargement and/or dilation, have an important role in arrhythmia initiation and perpetuation. Here, we review the various imaging techniques and modalities used by clinical and basic electrophysiologists to study cardiac arrhythmia mechanisms, periprocedural planning, risk stratification and precise delivery of ablation therapy. We also review the use of artificial intelligence and machine learning to improve identification of areas for triggered activity and isthmuses in reentrant arrhythmias, which may be favorable ablation targets.

Chronic diseases are closely linked to alterations in body composition, yet there is a need for reliable biomarkers to assess disease risk and progression. This study aimed to develop and validate a biological age indicator based on body composition derived from dual-energy X-ray absorptiometry (DXA) scans, offering a novel approach to evaluating health status and predicting disease outcomes. A deep learning model was trained on a reference population from the UK Biobank to estimate body composition biological age (BCBA). The model's performance was assessed across various groups, including individuals with typical and atypical body composition, those with pre-existing diseases, and those who developed diseases after DXA imaging. Key metrics such as c-index were employed to examine BCBA's diagnostic and prognostic potential for type 2 diabetes, major adverse cardiovascular events (MACE), atherosclerotic cardiovascular disease (ASCVD), and hypertension. Here we show that BCBA strongly correlates with chronic disease diagnoses and risk prediction. BCBA demonstrated significant associations with type 2 diabetes (odds ratio 1.08 for females and 1.04 for males, p < 0.0005), MACE (odds ratio 1.10 for females and 1.11 for males, p < 0.0005), ASCVD (odds ratio 1.07 for females and 1.10 for males, p < 0.0005), and hypertension (odds ratio 1.06 for females and 1.04 for males, p < 0.0005). It outperformed standard cardiovascular risk profiles in predicting MACE and ASCVD. BCBA is a promising biomarker for assessing chronic disease risk and progression, with potential to improve clinical decision-making. Its integration into routine health assessments could aid early disease detection and personalised interventions.

The rapid spread of SARS-CoV-2 has highlighted the need for intelligent methodologies in COVID-19 diagnosis. Clinicians face significant challenges due to the virus's fast transmission rate and the lack of reliable diagnostic tools. Although artificial intelligence (AI) has improved image processing, conventional approaches still rely on centralized data storage and training. This reliance increases complexity and raises privacy concerns, which hinder global data exchange. Therefore, it is essential to develop collaborative models that balance accuracy with privacy protection. This research presents a novel framework that combines blockchain technology with a combined learning paradigm to ensure secure data distribution and reduced complexity. The proposed Combined Learning Collective Deep Learning Blockchain Model (CLCD-Block) aggregates data from multiple institutions and leverages a hybrid capsule learning network for accurate predictions. Extensive testing with lung CT images demonstrates that the model outperforms existing models, achieving an accuracy exceeding 97%. Specifically, on four benchmark datasets, CLCD-Block achieved up to 98.79% Precision, 98.84% Recall, 98.79% Specificity, 98.81% F1-Score, and 98.71% Accuracy, showcasing its superior diagnostic capability. Designed for COVID-19 diagnosis, the CLCD-Block framework is adaptable to other applications, integrating AI, decentralized training, privacy protection, and secure blockchain collaboration. It addresses challenges in diagnosing chronic diseases, facilitates cross-institutional research and monitors infectious outbreaks. Future work will focus on enhancing scalability, optimizing real-time performance and adapting the model for broader healthcare datasets.

Artificial intelligence applications in oncology imaging often struggle with diagnosing rare tumors. We identify significant gaps in detecting uncommon thyroid cancer types with ultrasound, where scarce data leads to frequent misdiagnosis. Traditional augmentation strategies do not capture the unique disease variations, hindering model training and performance. To overcome this, we propose a text-driven generative method that fuses clinical insights with image generation, producing synthetic samples that realistically reflect rare subtypes. In rigorous evaluations, our approach achieves substantial gains in diagnostic metrics, surpasses existing methods in authenticity and diversity measures, and generalizes effectively to other private and public datasets with various rare cancers. In this work, we demonstrate that text-guided image augmentation substantially enhances model accuracy and robustness for rare tumor detection, offering a promising avenue for more reliable and widespread clinical adoption.

Deep learning reconstruction (DLR) provides an elegant solution for MR acceleration while preserving image quality. This advancement is crucial for body imaging, which is frequently marred by the increased likelihood of motion-related artifacts. Multiple vendor-specific models focusing on T2, T1, and diffusion-weighted imaging have been developed for the abdomen, pelvis, and chest, with the liver and prostate being the most well-studied organ systems. Variational networks with supervised DL models, including data consistency layers and regularizers, are the most common DLR methods. The common theme for all single-center studies on this subject has been noninferior or superior image quality metrics and lesion conspicuity to conventional sequences despite significant acquisition time reduction. DLR also provides a potential for denoising, artifact reduction, increased resolution, and increased signal-noise ratio (SNR) and contrast-to-noise ratio (CNR) that can be balanced with acceleration benefits depending on the imaged organ system. Some specific challenges faced by DLR include slightly reduced lesion detection, cardiac motion-related signal loss, regional SNR variations, and variabilities in ADC measurements as reported in different organ systems. Continued investigations with large-scale multicenter prospective clinical validation of DLR to document generalizability and demonstrate noninferior diagnostic accuracy with histopathologic correlation are the need of the hour. The creation of vendor-neutral solutions, open data sharing, and diversifying training data sets are also critical to strengthening model robustness.

Artificial intelligence (AI) has become pivotal in advancing medical care, particularly in interventional cardiology. Recent AI developments have proven effective in guiding advanced procedures and complex decisions. The authors review the latest AI-based innovations in the diagnosis of chronic total occlusions (CTO) and in determining the probability of success of CTO percutaneous coronary intervention (PCI). Neural networks and deep learning strategies were the most commonly used algorithms, and the models were trained and deployed using a variety of data types, such as clinical parameters and imaging. AI holds great promise in facilitating CTO PCI.

Sincalide-stimulated cholescintigraphy (SSC) calculates the gallbladder ejection fraction (GBEF) to diagnose functional gallbladder disorder. Currently, artificial intelligence (AI)-driven workflows that integrate real-time image processing and organ function calculation remain unexplored in nuclear medicine practice. This pilot study explored an AI-based application for gallbladder radioactivity tracking. We retrospectively analyzed 20 SSC exams, categorized into 10 easy and 10 challenging cases. Two human operators (H1 and H2) independently annotated the gallbladder regions of interest manually over the course of the 60-minute SSC. A U-Net-based deep learning model was developed to automatically segment gallbladder masks, and a 10-fold cross-validation was performed for both easy and challenging cases. The AI-generated masks were compared with human-annotated ones, with Dice similarity coefficients (DICE) used to assess agreement. AI achieved an average DICE of 0.746 against H1 and 0.676 against H2, performing better in easy cases (0.781) than in challenging ones (0.641). Visual inspection showed AI was prone to errors with patient motion or low-count activity. This study highlights AI's potential in real-time gallbladder tracking and GBEF calculation during SSC. AI-enabled real-time evaluation of nuclear imaging data holds promise for advancing clinical workflows by providing instantaneous organ function assessments and feedback to technologists. This AI-enabled workflow could enhance diagnostic efficiency, reduce scan duration, and improve patient comfort by alleviating symptoms associated with SSC, such as abdominal discomfort due to sincalide administration.