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Integrating big data and artificial intelligence to predict progression in multiple sclerosis: challenges and the path forward.

Authors

Khan H,Aerts S,Vermeulen I,Woodruff HC,Lambin P,Peeters LM

Affiliations (7)

  • Biomedical Research Institute (BIOMED), University MS Center, Hasselt University, Agoralaan Building C, 3590, Diepenbeek, Belgium.
  • Data Science Institute (DSI), Hasselt University, Agoralaan Building D, 3590, Diepenbeek, Belgium.
  • The D-Lab, Department of Precision Medicine, GROW Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, Netherlands.
  • UHasselt, Rehabilitation Research Centre (REVAL), Faculty of Rehabilitation Sciences, Wetenschapspark 7, 3590, Diepenbeek, Belgium.
  • Department of Radiology and Nuclear Medicine, GROW Research Institute for Oncology and Reproduction, Maastricht University Medical Center+, Maastricht, Netherlands.
  • Biomedical Research Institute (BIOMED), University MS Center, Hasselt University, Agoralaan Building C, 3590, Diepenbeek, Belgium. [email protected].
  • Data Science Institute (DSI), Hasselt University, Agoralaan Building D, 3590, Diepenbeek, Belgium. [email protected].

Abstract

Multiple sclerosis (MS) remains a complex and costly neurological condition characterised by progressive disability, making early detection and accurate prognosis of disease progression imperative. While artificial intelligence (AI) combined with big data promises transformative advances in personalised MS care, integration of multimodal, real-world datasets, including clinical records, magnetic resonance imaging (MRI), and digital biomarkers, remains limited. This perspective paper identifies a critical gap between technical innovation and clinical implementation, driven by methodological constraints, evolving regulatory frameworks, and ethical concerns related to bias, privacy, and equity. We explore this gap through three interconnected lenses: the underuse of integrated real-world data, the barriers posed by regulation and ethics, and emerging solutions. Promising strategies such as federated learning, regulatory initiatives like DARWIN-EU and the European Health Data Space, and patient-led frameworks including PROMS and CLAIMS, offer structured pathways forward. Additionally, we highlight the growing relevance of foundation models for interpreting complex MS data and supporting clinical decision-making. We advocate for harmonised data infrastructures, patient-centred design, explainable AI, and real-world validation as core pillars for future implementation. By aligning technical, regulatory, and ethical domains, stakeholders can unlock the full potential of AI to enhance prognosis, personalise care, and improve outcomes for people with MS.

Topics

Multiple SclerosisArtificial IntelligenceBig DataDisease ProgressionJournal ArticleReview

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