Group-derived and individual disconnection in stroke: recovery prediction and deep graph learning

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Abstract

Recent advances in the treatment of acute ischemic stroke contribute to improved patient outcomes, yet the mechanisms driving long-term disease trajectory are not well-understood. Current trends in the literature emphasize the distributed disruptive impact of stroke lesions on brain network organization. While most studies use population-derived data to investigate lesion interference on healthy tissue, the potential for individualized treatment strategies remains underexplored due to a lack of availability and effective utilization of the necessary clinical imaging data. To validate the potential for individualized patient evaluation, we explored and compared the differential information in network models based on normative and individual data. We further present our novel deep learning approach providing usable and accurate estimates of individual stroke impact utilizing minimal imaging data, thus bridging the data gap hindering individualized treatment planning. We created normative and individual disconnectomes for each of 78 patients (mean age 65.1 years, 32 females) from two independent cohort studies. MRI data and Barthel Index, as a measure of activities of daily living, were collected in the acute and early sub-acute phase after stroke (baseline) and at three months post stroke incident. Disconnectomes were subsequently described using 12 network metrics, including clustering coefficient and transitivity. Metrics were first compared between disconnectomes and further utilized as features in a classifier to predict a patients disease trajectory, as defined by three months Barthel Index. We then developed a deep learning architecture based on graph convolution and trained it to predict properties of the individual disconnectomes from the normative disconnectomes. Both disconnectomes showed statistically significant differences in topology and predictive power. Normative disconnectomes included a statistically significant larger number of connections (N=604 for normative versus N=210 for individual) and agreement between network properties ranged from r2=0.01 for clustering coefficient to r2=0.8 for assortativity, highlighting the impact of disconnectome choice on subsequent analysis. To predict patient deficit severity, individual data achieved an AUC score of 0.94 compared to an AUC score of 0.85 for normative based features. Our deep learning estimates showed high correlation with individual features (mean r2=0.94) and a comparable performance with an AUC score of 0.93. We were able to show how normative data-based analysis of stroke disconnections provides limited information regarding patient recovery. In contrast, individual data provided higher prognostic precision. We presented a novel approach to curb the need for individual data while retaining most of the differential information encoding individual patient disease trajectory.

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