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Enhanced brain tumor segmentation in medical imaging using multi-modal multi-scale contextual aggregation and attention fusion.

October 24, 2025pubmed logopapers

Authors

Aslam W,Hussain J,Aslam MZ,Jan S,Riaz TB,Iqbal A,Arif M,Khan I

Affiliations (6)

  • Department of Computer Science, Sir Syed CASE Institute of Technology, Islamabad, Pakistan.
  • Faculty of Computer Studies, Arab Open University, A'ali, 732, Kingdom of Bahrain. [email protected].
  • Department of Electrical Engineering, College of Electrical and Mechanical Engineering, NUST, Rawalpindi, Pakistan.
  • School of Computer Science and Engineering, Yeungnam University, Gyeongsan-si, 38541, Republic of Korea.
  • Department of Computer Engineering, Gachon University, Seongnam-si, 13120, Republic of Korea. [email protected].
  • Department of Computer Science, University of Engineering and Technology, Mardan, Pakistan.

Abstract

Accurate segmentation of brain tumors from multi-modal MRI scans is critical for diagnosis, treatment planning, and disease monitoring. Tumor heterogeneity and inter-image variability across MRI sequences pose challenging problems to state-of-the-art segmentation models. This paper presents a novel Multi-Modal Multi-Scale Contextual Aggregation with Attention Fusion (MM-MSCA-AF) framework that leverages multi-modal MRI images (T1, T2, FLAIR, and T1-CE) to enhance segmentation performance. The model employs multi-scale contextual aggregation to obtain global and fine-grained spatial features, and gated attention fusion for selectively refining effective feature representations and discarding noise. Evaluated on the BRATS 2020 dataset, MM-MSCA-AF achieves a Dice value of 0.8158 for necrotic tumor regions and 0.8589 in total, outperforming state-of-the-art architectures such as U-Net, nnU-Net, and Attention U-Net. These results demonstrate the effectiveness of MM-MSCA-AF in handling complex tumor shapes and improving segmentation accuracy. The proposed approach has significant clinical value, offering a more accurate and automatic brain tumor segmentation solution in medical imaging.

Topics

Brain NeoplasmsMagnetic Resonance ImagingImage Processing, Computer-AssistedMultimodal ImagingImage Interpretation, Computer-AssistedJournal Article

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