Deep learning model using CT images for longitudinal prediction of benign and malignant ground-glass nodules.
Authors
Affiliations (5)
Affiliations (5)
- Department of Radiology, Harbin Medical University, Harbin Medical University Cancer Hospital, 150 Haping Road, Harbin, Heilongjiang 150081, China.
- Department of Radiology, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, China.
- Department of Radiology, Beidahuang Industry Group General Hospital, Harbin 150001, China.
- Department of Radiology, Harbin Medical University, Harbin Medical University Cancer Hospital, 150 Haping Road, Harbin, Heilongjiang 150081, China; Department of Radiology, The Second Affiliated Hospital of Mudanjiang Medical University, Mudanjiang City, Heilongjiang Province 157000, China. Electronic address: [email protected].
- Department of Radiology, Harbin Medical University, Harbin Medical University Cancer Hospital, 150 Haping Road, Harbin, Heilongjiang 150081, China. Electronic address: [email protected].
Abstract
To develop and validate a CT image-based multiple time-series deep learning model for the longitudinal prediction of benign and malignant pulmonary ground-glass nodules (GGNs). A total of 486 GGNs from an equal number of patients were included in this research, which took place at two medical centers. Each nodule underwent surgical removal and was confirmed pathologically. The patients were randomly assigned to a training set, validation set, and test set, following a distribution ratio of 7:2:1. We established a transformer-based deep learning framework that leverages multi-temporal CT images for the longitudinal prediction of GGNs, focusing on distinguishing between benign and malignant types. Additionally, we utilized 13 different machine learning algorithms to formulate clinical models, delta-radiomics models, and combined models that merge deep learning with CT semantic features. The predictive capabilities of the models were assessed using the receiver operating characteristic (ROC) curve and the area under the curve (AUC). The multiple time-series deep learning model based on CT images surpassed both the clinical model and the delta-radiomics model, showcasing strong predictive capabilities for GGNs across the training, validation, and test sets, with AUCs of 0.911 (95% CI, 0.879-0.939), 0.809 (95% CI,0.715-0.908), and 0.817 (95% CI,0.680-0.937), respectively. Furthermore, the models that integrated deep learning with CT semantic features achieved the highest performance, resulting in AUCs of 0.960 (95% CI, 0.912-0.977), 0.878 (95% CI,0.801-0.942), and 0.890(95% CI, 0.790-0.968). The multiple time-series deep learning model utilizing CT images was effective in predicting benign and malignant GGNs.