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Contemporary, non-invasive imaging diagnosis of chronic coronary artery disease.

November 29, 2025pubmed logopapers

Authors

van der Bijl P,Gulati M,Saraste A,Marwick T,Kwong R,Blankstein R,Nieman K,Sengupta PP,van Rosendael A,Knuuti J,Bangalore S,Bax JJ

Affiliations (10)

  • Department of Cardiology, Leiden University Medical Centre, Leiden, Netherlands; SA Endovascular, Netcare Kuils River Hospital, Cape Town, South Africa.
  • Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Department of Internal Medicine, University of Turku, Turku, Finland.
  • Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.
  • Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA.
  • Centre for Academic Medicine, Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Palo Alto, CA, USA.
  • Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA.
  • Department of Cardiology, Leiden University Medical Centre, Leiden, Netherlands.
  • New York University Grossman School of Medicine, New York, NY, USA.
  • Department of Cardiology, Leiden University Medical Centre, Leiden, Netherlands. Electronic address: [email protected].

Abstract

Coronary artery disease is one of the leading causes of morbidity and mortality worldwide. Although it can present with an acute coronary syndrome, it is often characterised by long periods of stability, known as chronic coronary artery disease. This Review presents a comprehensive overview of the diagnosis of the disease, with a focus on cardiac imaging. We discuss various cardiac imaging modalities, including CT coronary angiography, stress echocardiogram, stress single-photon emission CT, PET, and stress cardiac magnetic resonance. We also compare the roles of anatomical (eg, CT coronary angiography) versus functional (eg, stress echocardiogram) tests and examine the potential utility of artificial intelligence in more detail.

Topics

Coronary Artery DiseaseCardiac Imaging TechniquesJournal ArticleReview

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