3D Convolutional Neural Network for Predicting Clinical Outcome from Coronary Computed Tomography Angiography in Patients with Suspected Coronary Artery Disease.
Authors
Affiliations (5)
Affiliations (5)
- Department of Cardiovascular Radiology and Nuclear Medicine,, TUM University Hospital, German Heart Center, Lazarettstrasse 36, Munich, 80636, Germany.
- Smart Robotics Lab, Department of Computer Engineering, Technical University of Munich, Munich, Germany.
- Diagnostic and Interventional Radiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
- Department of Cardiovascular Radiology and Nuclear Medicine,, TUM University Hospital, German Heart Center, Lazarettstrasse 36, Munich, 80636, Germany. [email protected].
- School of Medicine and Health, Technical University of Munich, Munich, Germany. [email protected].
Abstract
This study aims to develop and assess an optimized three-dimensional convolutional neural network model (3D CNN) for predicting major cardiac events from coronary computed tomography angiography (CCTA) images in patients with suspected coronary artery disease. Patients undergoing CCTA with suspected coronary artery disease (CAD) were retrospectively included in this single-center study and split into training and test sets. The endpoint was defined as a composite of all-cause death, myocardial infarction, unstable angina, or revascularization events. Cardiovascular risk assessment relied on Morise score and the extent of CAD (eoCAD). An optimized 3D CNN mimicking the DenseNet architecture was trained on CCTA images to predict the clinical endpoints. The data was unannotated for presence of coronary plaque. A total of 5562 patients were assigned to the training group (66.4% male, median age 61.1 ± 11.2); 714 to the test group (69.3% male, 61.5 ± 11.4). Over a 7.2-year follow-up, the composite endpoint occurred in 760 training group and 83 test group patients. In the test cohort, the CNN achieved an AUC of 0.872 ± 0.020 for predicting the composite endpoint. The predictive performance improved in a stepwise manner: from an AUC of 0.652 ± 0.031 while using Morise score alone to 0.901 ± 0.016 when adding eoCAD and finally to 0.920 ± 0.015 when combining Morise score, eoCAD, and CNN (p < 0.001 and p = 0.012, respectively). Deep learning-based analysis of CCTA images improves prognostic risk stratification when combined with clinical and imaging risk factors in patients with suspected CAD.