Role of machine learning segmentation method based on CT images in preoperative staging of oral cavity cancer.
Authors
Affiliations (5)
Affiliations (5)
- Faculty of Medicine, Department of Otorhinolaryngology and Head and Neck Surgery Clinic, Dicle University, Diyarbakır, Turkey. [email protected].
- Oncology Department, Head and Neck Cancer Unit, University of Turin, San Giovanni Bosco Hospital, Turin, Italy.
- Faculty of Engineering and Architecture, Department of Computer Engineering, Mardin Artuklu University, Mardin, Turkey.
- Department of Otorhinolaryngology-Head and Neck Surgery, Private Clinic, Ankara, Turkey.
- Faculty of Medicine, Department of Otorhinolaryngology and Head and Neck Surgery Clinic, Dicle University, Diyarbakır, Turkey.
Abstract
The article aims to demonstrate, using oral cavity SCC as an example, that machine learning can accurately predict the T and N staging of OSCC, using the conventional radiologist/ surgeon interpretation of the scan as the reference standard. Two datasets for tumor mass and nodal metastasis were used in this study. Each of the datasets consists of 179 Contrast-enhanced Computed Tomography images. A customized U-Net deep learning architecture was employed for the segmentation of tumor masses and nodal metastases. Comprehensive maps of the tumor mass and metastatic lymph nodes were generated. Following this mapping process, the dimensions of the identified lesions were measured and classified according to the Tumor and Lymph Node Metastasis classification system. The resulting classifications were then compared with those established by a radiologist to assess accuracy. The performance metrics for tumor mass and metastasis segmentation were as follows: binary accuracy value of 98.81% and 99.58%, respectively. The accuracy values were 75.00% for tumor grade classification and 97.22% for nodal status classification. We emphasize that machine learning-based segmentation methods effectively predict tumor mapping and staging in oral cavity tumors, demonstrating correlation with surgeons/radiologists' assessments. As such, this model can be a diagnostic tool that supports clinicians in making informed therapeutic decisions. We foresee that, with the continuous evolution of technology, the segmentation model employed in our study will undergo significant advancements, ultimately facilitating three-dimensional tumor mapping in the near future.