Attention-based deep learning network for predicting World Health Organization meningioma grade and Ki-67 expression based on magnetic resonance imaging.
Authors
Affiliations (7)
Affiliations (7)
- Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
- Department of Neurosurgery, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
- The First Clinical School of Nanjing Medical University, Nanjing, China.
- Institute for Brain Tumors, Jiangsu Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China.
- Department of Neurosurgery, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China. [email protected].
- Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. [email protected].
- Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. [email protected].
Abstract
Preoperative assessment of World Health Organization (WHO) meningioma grading and Ki-67 expression is crucial for treatment strategies. We aimed to develop a fully automated attention-based deep learning network to predict WHO meningioma grading and Ki-67 expression. This retrospective study included 952 meningioma patients, divided into training (n = 542), internal validation (n = 96), and external test sets (n = 314). For each task, clinical, radiomics, and deep learning models were compared. We used no-new-Unet (nn-Unet) models to construct the segmentation network, followed by four classification models using ResNet50 or Swin Transformer architectures with 2D or 2.5D input strategies. All deep learning models incorporated attention mechanisms. Both the segmentation and 2.5D classification models demonstrated robust performance on the external test set. The segmentation network achieved Dice coefficients of 0.98 (0.97-0.99) and 0.87 (0.83-0.91) for brain parenchyma and tumour segmentation. For predicting meningioma grade, the 2.5D ResNet50 achieved the highest area under the curve (AUC) of 0.90 (0.85-0.93), significantly outperforming the clinical (AUC = 0.77 [0.70-0.83], p < 0.001) and radiomics models (AUC = 0.80 [0.75-0.85], p < 0.001). For Ki-67 expression prediction, the 2.5D Swin Transformer achieved the highest AUC of 0.89 (0.85-0.93), outperforming both the clinical (AUC = 0.76 [0.71-0.81], p < 0.001) and radiomics models (AUC = 0.82 [0.77-0.86], p = 0.002). Our automated deep learning network demonstrated superior performance. This novel network could support more precise treatment planning for meningioma patients. Question Can artificial intelligence accurately assess meningioma WHO grade and Ki-67 expression from preoperative MRI to guide personalised treatment and follow-up strategies? Findings The attention-enhanced nn-Unet segmentation achieved high accuracy, while 2.5D deep learning models with attention mechanisms achieved accurate prediction of grades and Ki-67. Clinical relevance Our fully automated 2.5D deep learning model, enhanced with attention mechanisms, accurately predicts WHO grades and Ki-67 expression levels in meningiomas, offering a robust, objective, and non-invasive solution to support clinical diagnosis and optimise treatment planning.