Relationship between spleen volume and diameter for assessment of response to treatment on CT in patients with hematologic malignancies enrolled in clinical trials.
Authors
Affiliations (3)
Affiliations (3)
- Department of Mathematics and Statistics, San Diego State University, San Diego, USA.
- OncoRad Research Core, Department of Radiology, Fred Hutchinson Cancer Center, University of Washington, Seattle, WA, USA.
- OncoRad Research Core, Department of Radiology, Fred Hutchinson Cancer Center, University of Washington, Seattle, WA, USA. [email protected].
Abstract
Investigate spleen diameter (d) and volume (v) relationship in patients with hematologic malignancies (HM) by determining volumetric thresholds that best correlate to established diameter thresholds for assessing response to treatment. Exploratorily, interrogate the impact of volumetric measurements in response categories and as a predictor of response. Secondary analysis of prospectively collected clinical trial data of 382 patients with HM. Spleen diameters were computed following Lugano criteria and volumes using deep learning segmentation. d and v relationship was estimated using power regression model, volumetric thresholds ([Formula: see text]) for treatment response estimated; threshold search to determine percentual change ([Formula: see text] and minimum volumetric increase ([Formula: see text]) that maximize agreement with Lugano criteria performed. Spleen diameter and volume predictive performance for clinical response investigated using random forest model. [Formula: see text] describes the relationship between spleen diameter and volume. [Formula: see text] for splenomegaly was 546 cm³. [Formula: see text], [Formula: see text], and [Formula: see text] for assessing response resulting in highest agreement with Lugano criteria were 570 cm<sup>3</sup>, 73%, and 170 cm<sup>3</sup>, respectively. Predictive performance for response between diameter and volume were not significantly different (P=0.78). This study provides empirical spleen volume threshold and percentual changes that best correlate with diameter thresholds, i.e., Lugano criteria, for assessment of response to treatment in patients with HM. In our dataset use of spleen volumetric thresholds versus diameter thresholds resulted in similar response assessment categories and did not signal differences in predictive values for response.