Mice with ischemic stroke receiving human neural stem cell transplants showed robust brain recovery, measured using AI-based limb tracking.
Key Details
- 1Researchers from USC, University of Zurich, and ETH Zurich transplanted reprogrammed human blood cells (neural stem cells) into post-stroke mice brains.
- 2Stem cell transplants performed one week after stroke enhanced neuron and blood vessel growth, reduced inflammation, and improved neuronal connectivity.
- 3AI-powered movement analysis tracked significant functional improvements in motor skills and gait among treated mice.
- 4Majority of transplanted cells became GABAergic neurons, important for brain recovery.
- 5Study published in Nature Communications (DOI:10.1038/S41467-025-63725-3).
Why It Matters
The study demonstrates how AI-driven analysis can objectively measure neurological recovery in preclinical models, and highlights the translational potential of combining stem cell therapy and AI-based functional assessment for brain repair research.
Source
EurekAlert
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