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Scientific Evidence for Clinical Text Summarization Using Large Language Models: Scoping Review.

Bednarczyk L, Reichenpfader D, Gaudet-Blavignac C, Ette AK, Zaghir J, Zheng Y, Bensahla A, Bjelogrlic M, Lovis C

pubmed logopapersMay 15 2025
Information overload in electronic health records requires effective solutions to alleviate clinicians' administrative tasks. Automatically summarizing clinical text has gained significant attention with the rise of large language models. While individual studies show optimism, a structured overview of the research landscape is lacking. This study aims to present the current state of the art on clinical text summarization using large language models, evaluate the level of evidence in existing research and assess the applicability of performance findings in clinical settings. This scoping review complied with the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) guidelines. Literature published between January 1, 2019, and June 18, 2024, was identified from 5 databases: PubMed, Embase, Web of Science, IEEE Xplore, and ACM Digital Library. Studies were excluded if they did not describe transformer-based models, did not focus on clinical text summarization, did not engage with free-text data, were not original research, were nonretrievable, were not peer-reviewed, or were not in English, French, Spanish, or German. Data related to study context and characteristics, scope of research, and evaluation methodologies were systematically collected and analyzed by 3 authors independently. A total of 30 original studies were included in the analysis. All used observational retrospective designs, mainly using real patient data (n=28, 93%). The research landscape demonstrated a narrow research focus, often centered on summarizing radiology reports (n=17, 57%), primarily involving data from the intensive care unit (n=15, 50%) of US-based institutions (n=19, 73%), in English (n=26, 87%). This focus aligned with the frequent reliance on the open-source Medical Information Mart for Intensive Care dataset (n=15, 50%). Summarization methodologies predominantly involved abstractive approaches (n=17, 57%) on single-document inputs (n=4, 13%) with unstructured data (n=13, 43%), yet reporting on methodological details remained inconsistent across studies. Model selection involved both open-source models (n=26, 87%) and proprietary models (n=7, 23%). Evaluation frameworks were highly heterogeneous. All studies conducted internal validation, but external validation (n=2, 7%), failure analysis (n=6, 20%), and patient safety risks analysis (n=1, 3%) were infrequent, and none reported bias assessment. Most studies used both automated metrics and human evaluation (n=16, 53%), while 10 (33%) used only automated metrics, and 4 (13%) only human evaluation. Key barriers hinder the translation of current research into trustworthy, clinically valid applications. Current research remains exploratory and limited in scope, with many applications yet to be explored. Performance assessments often lack reliability, and clinical impact evaluations are insufficient raising concerns about model utility, safety, fairness, and data privacy. Advancing the field requires more robust evaluation frameworks, a broader research scope, and a stronger focus on real-world applicability.

Metal Suppression Magnetic Resonance Imaging Techniques in Orthopaedic and Spine Surgery.

Ziegeler K, Yoon D, Hoff M, Theologis AA

pubmed logopapersMay 15 2025
Implantation of metallic instrumentation is the mainstay of a variety of orthopaedic and spine surgeries. Postoperatively, imaging of the soft tissues around these implants is commonly required to assess for persistent, recurrent, and/or new pathology (ie, instrumentation loosening, particle disease, infection, neural compression); visualization of these pathologies often requires the superior soft-tissue contrast of magnetic resonance imaging (MRI). As susceptibility artifacts from ferromagnetic implants can result in unacceptable image quality, unique MRI approaches are often necessary to provide accurate imaging. In this text, a comprehensive review is provided on common artifacts encountered in orthopaedic MRI, including comparisons of artifacts from different metallic alloys and common nonpropriety/propriety MR metallic artifact reduction methods. The newest metal-artifact suppression imaging technology and future directions (ie, deep learning/artificial intelligence) in this important field will be considered.

[Radiosurgery of benign intracranial lesions. Indications, results , and perspectives].

Danthez N, De Cournuaud C, Pistocchi S, Aureli V, Giammattei L, Hottinger AF, Schiappacasse L

pubmed logopapersMay 14 2025
Stereotactic radiosurgery (SRS) is a non-invasive technique that is transforming the management of benign intracranial lesions through its precision and preservation of healthy tissues. It is effective for meningiomas, trigeminal neuralgia (TN), pituitary adenomas, vestibular schwannomas, and arteriovenous malformations. SRS ensures high tumor control rates, particularly for Grade I meningiomas and vestibular schwannomas. For refractory TN, it provides initial pain relief > 80 %. The advent of technologies such as PET-MRI, hypofractionation, and artificial intelligence is further improving treatment precision, but challenges remain, including the management of late side effects and standardization of practice.

Privacy-preserving Federated Learning and Uncertainty Quantification in Medical Imaging.

Koutsoubis N, Waqas A, Yilmaz Y, Ramachandran RP, Schabath MB, Rasool G

pubmed logopapersMay 14 2025
<i>"Just Accepted" papers have undergone full peer review and have been accepted for publication in <i>Radiology: Artificial Intelligence</i>. This article will undergo copyediting, layout, and proof review before it is published in its final version. Please note that during production of the final copyedited article, errors may be discovered which could affect the content.</i> Artificial Intelligence (AI) has demonstrated strong potential in automating medical imaging tasks, with potential applications across disease diagnosis, prognosis, treatment planning, and posttreatment surveillance. However, privacy concerns surrounding patient data remain a major barrier to the widespread adoption of AI in clinical practice, as large and diverse training datasets are essential for developing accurate, robust, and generalizable AI models. Federated Learning offers a privacy-preserving solution by enabling collaborative model training across institutions without sharing sensitive data. Instead, model parameters, such as model weights, are exchanged between participating sites. Despite its potential, federated learning is still in its early stages of development and faces several challenges. Notably, sensitive information can still be inferred from the shared model parameters. Additionally, postdeployment data distribution shifts can degrade model performance, making uncertainty quantification essential. In federated learning, this task is particularly challenging due to data heterogeneity across participating sites. This review provides a comprehensive overview of federated learning, privacy-preserving federated learning, and uncertainty quantification in federated learning. Key limitations in current methodologies are identified, and future research directions are proposed to enhance data privacy and trustworthiness in medical imaging applications. ©RSNA, 2025.

The Future of Urodynamics: Innovations, Challenges, and Possibilities.

Chew LE, Hannick JH, Woo LL, Weaver JK, Damaser MS

pubmed logopapersMay 14 2025
Urodynamic studies (UDS) are essential for evaluating lower urinary tract function but are limited by patient discomfort, lack of standardization and diagnostic variability. Advances in technology aim to address these challenges and improve diagnostic accuracy and patient comfort. AUM offers physiological assessment by allowing natural bladder filling and monitoring during daily activities. Compared to conventional UDS, AUM demonstrates higher sensitivity for detecting detrusor overactivity and underlying pathophysiology. However, it faces challenges like motion artifacts, catheter-related discomfort, and difficulty measuring continuous bladder volume. Emerging devices such as Urodynamics Monitor and UroSound offer more patient-friendly alternatives. These tools have the potential to improve diagnostic accuracy for bladder pressure and voiding metrics but remain limited and still require further validation and testing. Ultrasound-based modalities, including dynamic ultrasonography and shear wave elastography, provide real-time, noninvasive assessment of bladder structure and function. These modalities are promising but will require further development of standardized protocols. AI and machine learning models enhance diagnostic accuracy and reduce variability in UDS interpretation. Applications include detecting detrusor overactivity and distinguishing bladder outlet obstruction from detrusor underactivity. However, further validation is required for clinical adoption. Advances in AUM, wearable technologies, ultrasonography, and AI demonstrate potential for transforming UDS into a more accurate, patient-centered tool. Despite significant progress, challenges like technical complexity, standardization, and cost-effectiveness must be addressed to integrate these innovations into routine practice. Nonetheless, these technologies provide the possibility of a future of improved diagnosis and treatment of lower urinary tract dysfunction.

[Pulmonary vascular interventions: innovating through adaptation and advancing through differentiation].

Li J, Wan J

pubmed logopapersMay 12 2025
Pulmonary vascular intervention technology, with its minimally invasive and precise advantages, has been a groundbreaking advancement in the treatment of pulmonary vascular diseases. Techniques such as balloon pulmonary angioplasty (BPA), pulmonary artery stenting, and percutaneous pulmonary artery denervation (PADN) have significantly improved the prognoses for conditions such as chronic thromboembolic pulmonary hypertension (CTEPH), pulmonary artery stenosis, and pulmonary arterial hypertension (PAH). Although based on coronary intervention (PCI) techniques such as guidewire manipulation and balloon dilatation, pulmonary vascular interventions require specific modifications to address the unique characteristics of the pulmonary circulation, low pressure, thin-walled vessels, and complex branching, to mitigate risks of perforation and thrombosis. Future directions include the development of dedicated instruments, multi-modality imaging guidance, artificial intelligence-assisted procedures, and molecular interventional therapies. These innovations aim to establish an independent theoretical framework for pulmonary vascular interventions, facilitating their transition from "adjuvant therapies" to "core treatments" in clinical practice.

Cardiac imaging for the detection of ischemia: current status and future perspectives.

Rodriguez C, Pappas L, Le Hong Q, Baquero L, Nagel E

pubmed logopapersMay 12 2025
Coronary artery disease is the main cause of mortality worldwide mandating early detection, appropriate treatment, and follow-up. Noninvasive cardiac imaging techniques allow detection of obstructive coronary heart disease by direct visualization of the arteries or myocardial blood flow reduction. These techniques have made remarkable progress since their introduction, achieving high diagnostic precision. This review aims at evaluating these noninvasive cardiac imaging techniques, rendering a thorough overview of diagnostic decision-making for detection of ischemia. We discuss the latest advances in the field such as computed tomography angiography, single-photon emission tomography, positron emission tomography, and cardiac magnetic resonance; their main advantages and disadvantages, their most appropriate use and prospects. For the review, we analyzed the literature from 2009 to 2024 on noninvasive cardiac imaging in the diagnosis of coronary artery disease. The review included the 78 publications considered most relevant, including landmark trials, review articles and guidelines. The progress in cardiac imaging is anticipated to overcome various limitations such as high costs, radiation exposure, artifacts, and differences in interpretation among observers. It is expected to lead to more automated scanning processes, and with the assistance of artificial intelligence-driven post-processing software, higher accuracy and reproducibility may be attained.

Insights into radiomics: a comprehensive review for beginners.

Mariotti F, Agostini A, Borgheresi A, Marchegiani M, Zannotti A, Giacomelli G, Pierpaoli L, Tola E, Galiffa E, Giovagnoni A

pubmed logopapersMay 12 2025
Radiomics and artificial intelligence (AI) are rapidly evolving, significantly transforming the field of medical imaging. Despite their growing adoption, these technologies remain challenging to approach due to their technical complexity. This review serves as a practical guide for early-career radiologists and researchers seeking to integrate radiomics into their studies. It provides practical insights for clinical and research applications, addressing common challenges, limitations, and future directions in the field. This work offers a structured overview of the essential steps in the radiomics workflow, focusing on concrete aspects of each step, including indicative and practical examples. It covers the main steps such as dataset definition, image acquisition and preprocessing, segmentation, feature extraction and selection, and AI model training and validation. Different methods to be considered are discussed, accompanied by summary diagrams. This review equips readers with the knowledge necessary to approach radiomics and AI in medical imaging from a hands-on research perspective.

Medical machine learning operations: a framework to facilitate clinical AI development and deployment in radiology.

de Almeida JG, Messiou C, Withey SJ, Matos C, Koh DM, Papanikolaou N

pubmed logopapersMay 8 2025
The integration of machine-learning technologies into radiology practice has the potential to significantly enhance diagnostic workflows and patient care. However, the successful deployment and maintenance of medical machine-learning (MedML) systems in radiology requires robust operational frameworks. Medical machine-learning operations (MedMLOps) offer a structured approach ensuring persistent MedML reliability, safety, and clinical relevance. MedML systems are increasingly employed to analyse sensitive clinical and radiological data, which continuously changes due to advancements in data acquisition and model development. These systems can alleviate the workload of radiologists by streamlining diagnostic tasks, such as image interpretation and triage. MedMLOps ensures that such systems stay accurate and dependable by facilitating continuous performance monitoring, systematic validation, and simplified model maintenance-all critical to maintaining trust in machine-learning-driven diagnostics. Furthermore, MedMLOps aligns with established principles of patient data protection and regulatory compliance, including recent developments in the European Union, emphasising transparency, documentation, and safe model retraining. This enables radiologists to implement modern machine-learning tools with control and oversight at the forefront, ensuring reliable model performance within the dynamic context of clinical practice. MedMLOps empowers radiologists to deliver consistent, high-quality care with confidence, ensuring that MedML systems stay aligned with evolving medical standards and patient needs. MedMLOps can assist multiple stakeholders in radiology by ensuring models are available, continuously monitored and easy to use and maintain while preserving patient privacy. MedMLOps can better serve patients by facilitating the clinical implementation of cutting-edge MedML and clinicians by ensuring that MedML models are only utilised when they are performing as expected. KEY POINTS: Question MedML applications are becoming increasingly adopted in clinics, but the necessary infrastructure to sustain these applications is currently not well-defined. Findings Adapting machine learning operations concepts enhances MedML ecosystems by improving interoperability, automating monitoring/validation, and reducing deployment burdens on clinicians and medical informaticians. Clinical relevance Implementing these solutions eases the faster and safer adoption of advanced MedML models, ensuring consistent performance while reducing workload for clinicians, benefiting patient care through streamlined diagnostic workflows.

Prompt Engineering for Large Language Models in Interventional Radiology.

Dietrich N, Bradbury NC, Loh C

pubmed logopapersMay 7 2025
Prompt engineering plays a crucial role in optimizing artificial intelligence (AI) and large language model (LLM) outputs by refining input structure, a key factor in medical applications where precision and reliability are paramount. This Clinical Perspective provides an overview of prompt engineering techniques and their relevance to interventional radiology (IR). It explores key strategies, including zero-shot, one- or few-shot, chain-of-thought, tree-of-thought, self-consistency, and directional stimulus prompting, demonstrating their application in IR-specific contexts. Practical examples illustrate how these techniques can be effectively structured for workplace and clinical use. Additionally, the article discusses best practices for designing effective prompts and addresses challenges in the clinical use of generative AI, including data privacy and regulatory concerns. It concludes with an outlook on the future of generative AI in IR, highlighting advances including retrieval-augmented generation, domain-specific LLMs, and multimodal models.
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