Late gadolinium enhancement (LGE) cardiac magnetic resonance (CMR) imaging is considered the in vivo reference standard for assessing infarct size (IS) and microvascular obstruction (MVO) in ST-elevation myocardial infarction (STEMI) patients. However, the exact quantification of those markers of myocardial infarct severity remains challenging and very time-consuming. As LGE distribution patterns can be quite complex and hard to delineate from the blood pool or epicardial fat, automatic segmentation of LGE CMR images is challenging. In this work, we propose a cascaded framework of two-dimensional and three-dimensional convolutional neural networks (CNNs) which enables to calculate the extent of myocardial infarction in a fully automated way. By artificially generating segmentation errors which are characteristic for 2D CNNs during training of the cascaded framework we are enforcing the detection and correction of 2D segmentation errors and hence improve the segmentation accuracy of the entire method. The proposed method was trained and evaluated on two publicly available datasets. We perform comparative experiments where we show that our framework outperforms state-of-the-art reference methods in segmentation of myocardial infarction. Furthermore, in extensive ablation studies we show the advantages that come with the proposed error correcting cascaded method. The code of this project is publicly available at https://github.com/matthi99/EcorC.git.

Microwave thermotherapy is a promising approach for cancer treatment, but accurate noninvasive temperature monitoring remains challenging. This study aims to achieve accurate temperature prediction during microwave thermotherapy by efficiently integrating multi-feature data, thereby improving the accuracy and reliability of noninvasive thermometry techniques. We proposed an enhanced recurrent neural network architecture, namely CirnetamorNet. The experimental data acquisition system is developed by using the material that simulates the characteristics of human tissue to construct the body model. Ultrasonic image data at different temperatures were collected, and 5 parameters with high temperature correlation were extracted from gray scale covariance matrix and Homodyned-K distribution. Using multi-feature data as input and temperature prediction as output, the CirnetamorNet model is constructed by multi-head attention mechanism. Model performance was evaluated by analyzing training losses, predicting mean square error and accuracy, and ablation experiments were performed to evaluate the contribution of each module. Compared with common models, the CirnetamorNet model performs well, with training losses as low as 1.4589 and mean square error of only 0.1856. Its temperature prediction accuracy of 0.3°C exceeds that of many advanced models. Ablation experiments show that the removal of any key module of the model will lead to performance degradation, which proves that the collaboration of all modules is significant for improving the performance of the model. The proposed CirnetamorNet model exhibits exceptional performance in noninvasive thermometry for microwave thermotherapy. It offers a novel approach to multi-feature data fusion in the medical field and holds significant practical application value.

To evaluate the diagnostic performance of the PET Assisted Reporting System (PARS) in nasopharyngeal carcinoma (NPC) patients without distant metastasis, and to investigate the prognostic significance of the metabolic parameters. Eighty-three NPC patients who underwent pretreatment 18F-FDG PET/CT were retrospectively collected. First, the sensitivity, specificity, and accuracy of PARS for diagnosing malignant lesions were calculated, using histopathology as the gold standard. Next, metabolic parameters of the primary tumor were derived using both PARS and manual segmentation. The differences and consistency between the 2 methods were analyzed. Finally, the prognostic value of PET metabolic parameters was evaluated. Prognostic analysis of progression-free survival (PFS) and overall survival (OS) was conducted. PARS demonstrated high patient-based accuracy (97.2%), sensitivity (88.9%), and specificity (97.4%), and 96.7%, 84.0%, and 96.9% based on lesions. Manual segmentation yielded higher metabolic tumor volume (MTV) and total lesion glycolysis (TLG) than PARS. Metabolic parameters from both methods were highly correlated and consistent. ROC analysis showed metabolic parameters exhibited differences in prognostic prediction, but generally performed well in predicting 3-year PFS and OS overall. MTV and age were independent prognostic factors; Cox proportional-hazards models incorporating them showed significant predictive improvements when combined. Kaplan-Meier analysis confirmed better prognosis in the low-risk group based on combined indicators (χ² = 42.25, P < 0.001; χ² = 20.44, P < 0.001). Preliminary validation of PARS in NPC patients without distant metastasis shows high diagnostic sensitivity and accuracy for lesion identification and classification, and metabolic parameters correlate well with manual. MTV reflects prognosis, and its combination with age enhances prognostic prediction and risk stratification.

This study evaluates adherence to the latest Society for Vascular Surgery (SVS) guidelines on imaging surveillance, physician evaluation, and surgical intervention for abdominal aortic aneurysm (AAA). AI-based natural language processing applied retrospectively identified AAA patients from imaging scans at a tertiary care center between January-March 2019 and 2021, excluding the pandemic period. Retrospective chart review assessed demographics, comorbidities, imaging, and follow-up adherence. Statistical significance was set at p<0.05. Among 479 identified patients, 279 remained in the final cohort following exclusion of deceased patients. Imaging surveillance adherence was 67.7% (189/279), with males comprising 72.5% (137/189) (Figure 1). The mean age for adherent patients was 73.9 (SD ±9.5) vs. 75.2 (SD ±10.8) for non-adherent patients (Table 1). Adherent females were significantly younger than non-adherent females (76.7 vs. 81.1 years; p=0.003) with no significant age difference in adherent males. Adherent patients were more likely to be evaluated by a vascular provider within six months (p<0.001), but aneurysm size did not affect imaging adherence: 3.0-4.0cm (p=0.24), 4.0-5.0cm (p=0.88), >5.0cm (p=0.29). Based on SVS surgical criteria, 18 males (AAA >5.5cm) and 17 females (AAA >5.0cm) qualified for intervention and repair rates increased in 2021. 34 males (20 in 2019 v. 14 in 2021) and 7 females (2021 only) received surgical intervention below the threshold for repair. Despite consistent SVS guidelines, adherence remains moderate. AI-based detection and follow-up algorithms may enhance adherence and long-term AAA patient outcomes, however further research is needed to assess the specific impacts of AI.

In knee osteoarthritis (KOA) treatment, preventive measures to reduce its onset risk are a key factor. Among individuals with radiographically healthy knees, however, future knee joint integrity and condition cannot be predicted by clinically applicable methods. We investigated if knee joint morphology derived from widely accessible and cost-effective radiographs could be helpful in predicting future knee joint integrity and condition. We combined knee joint morphology with known risk predictors such as age, height, and weight. Baseline data were utilized as predictors, and the maximal severity of KOA after 8 years served as a target variable. The three KOA categories in this study were based on Kellgren-Lawrence grading: healthy, moderate, and severe. We employed a two-stage machine learning model that utilized two random forest algorithms. We trained three models: the subject demographics (SD) model utilized only SD; the image model utilized only knee joint morphology from radiographs; the merged model utilized combined predictors. The training data comprised an 8-year follow-up of 1222 knees from 683 individuals. The SD- model obtained a weighted F1 score (WF1) of 77.2% and a balanced accuracy (BA) of 65.6%. The Image-model performance metrics were lowest, with a WF1 of 76.5% and BA of 63.8%. The top-performing merged model achieved a WF1 score of 78.3% and a BA of 68.2%. Our two-stage prediction model provided improved results based on performance metrics, suggesting potential for application in clinical settings.

The distribution of visceral adipose tissue (VAT) in cystectomy patients is indicative of the incidence of postoperative complications. Existing VAT segmentation methods for computed tomography (CT) employing intensity thresholding have limitations relating to inter-observer variability. Moreover, the difficulty in creating ground-truth masks limits the development of deep learning (DL) models for this task. This paper introduces a novel method for VAT prediction in pre-cystectomy CT, which is fully automated and does not require ground-truth VAT masks for training, overcoming aforementioned limitations. We introduce the kernel density-enhanced VAT segmentator (KEVS), combining a DL semantic segmentation model, for multi-body feature prediction, with Gaussian kernel density estimation analysis of predicted subcutaneous adipose tissue to achieve accurate scan-specific predictions of VAT in the abdominal cavity. Uniquely for a DL pipeline, KEVS does not require ground-truth VAT masks. We verify the ability of KEVS to accurately segment abdominal organs in unseen CT data and compare KEVS VAT segmentation predictions to existing state-of-the-art (SOTA) approaches in a dataset of 20 pre-cystectomy CT scans, collected from University College London Hospital (UCLH-Cyst), with expert ground-truth annotations. KEVS presents a <math xmlns="http://www.w3.org/1998/Math/MathML"><mrow><mn>4.80</mn> <mo>%</mo></mrow> </math> and <math xmlns="http://www.w3.org/1998/Math/MathML"><mrow><mn>6.02</mn> <mo>%</mo></mrow> </math> improvement in Dice coefficient over the second best DL and thresholding-based VAT segmentation techniques respectively when evaluated on UCLH-Cyst. This research introduces KEVS, an automated, SOTA method for the prediction of VAT in pre-cystectomy CT which eliminates inter-observer variability and is trained entirely on open-source CT datasets which do not contain ground-truth VAT masks.

Pancreatic ductal adenocarcinoma (PDA) is an extremely metastatic and lethal disease. In PDA, extracellular matrix (ECM) architectures known as Tumor-Associated Collagen Signatures (TACS) regulate invasion and metastatic spread in both early dissemination and in late-stage disease. As such, TACS has been suggested as a biomarker to aid in pathologic assessment. However, despite its significance, approaches to quantitatively capture these ECM patterns currently require advanced optical systems with signaling processing analysis. Here we present an expansion of polychromatic polarized microscopy (PPM) with inherent angular information coupled to machine learning and computational pixel-wise analysis of TACS. Using this platform, we are able to accurately capture TACS architectures in H&E stained histology sections directly through PPM contrast. Moreover, PPM facilitated identification of transitions to dissemination architectures, i.e., transitions from sequestration through expansion to dissemination from both PanINs and throughout PDA. Lastly, PPM evaluation of architectures in liver metastases, the most common metastatic site for PDA, demonstrates TACS-mediated focal and local invasion as well as identification of unique patterns anchoring aligned fibers into normal-adjacent tumor, suggesting that these patterns may be precursors to metastasis expansion and local spread from micrometastatic lesions. Combined, these findings demonstrate that PPM coupled to computational platforms is a powerful tool for analyzing ECM architecture that can be employed to advance cancer microenvironment studies and provide clinically relevant diagnostic information.

Adaptive optics scanning light ophthalmoscopy (AOSLO) reveals individual retinal cells and their function, microvasculature, and micropathologies in vivo. As compared to the single-channel offset pinhole and two-channel split-detector nonconfocal AOSLO designs, by providing multidirectional imaging capabilities, a recent generation of multidetector and (multi-)offset aperture AOSLO modalities has been demonstrated to provide critical information about retinal microstructures. However, increasing detection channels requires expensive optical components and/or critically increases imaging time. To address this issue, we present an innovative combination of machine learning and optics as an integrated technology to compressively capture 12 nonconfocal channel AOSLO images simultaneously. Imaging of healthy participants and diseased subjects using the proposed deep compressed multichannel AOSLO showed enhanced visualization of rods, cones, and mural cells with over an order-of-magnitude improvement in imaging speed as compared to conventional offset aperture imaging. To facilitate the adaptation and integration with other in vivo microscopy systems, we made optical design, acquisition, and computational reconstruction codes open source.

The purpose of this study was to compare the ability of two multimodal models (GPT-4o and Gemini 1.5 Pro) with that of radiologists to generate differential diagnoses from textual context alone, key images alone, or a combination of both using complex neuroradiology cases. This retrospective study included neuroradiology cases from the "Diagnosis Please" series published in the Radiology journal between January 2008 and September 2024. The two multimodal models were asked to provide three differential diagnoses from textual context alone, key images alone, or the complete case. Six board-certified neuroradiologists solved the cases in the same setting, randomly assigned to two groups: context alone first and images alone first. Three radiologists solved the cases without, and then with the assistance of Gemini 1.5 Pro. An independent radiologist evaluated the quality of the image descriptions provided by GPT-4o and Gemini for each case. Differences in correct answers between multimodal models and radiologists were analyzed using McNemar test. GPT-4o and Gemini 1.5 Pro outperformed radiologists using clinical context alone (mean accuracy, 34.0 % [18/53] and 44.7 % [23.7/53] vs. 16.4 % [8.7/53]; both P < 0.01). Radiologists outperformed GPT-4o and Gemini 1.5 Pro using images alone (mean accuracy, 42.0 % [22.3/53] vs. 3.8 % [2/53], and 7.5 % [4/53]; both P < 0.01) and the complete cases (48.0 % [25.6/53] vs. 34.0 % [18/53], and 38.7 % [20.3/53]; both P < 0.001). While radiologists improved their accuracy when combining multimodal information (from 42.1 % [22.3/53] for images alone to 50.3 % [26.7/53] for complete cases; P < 0.01), GPT-4o and Gemini 1.5 Pro did not benefit from the multimodal context (from 34.0 % [18/53] for text alone to 35.2 % [18.7/53] for complete cases for GPT-4o; P = 0.48, and from 44.7 % [23.7/53] to 42.8 % [22.7/53] for Gemini 1.5 Pro; P = 0.54). Radiologists benefited significantly from the suggestion of Gemini 1.5 Pro, increasing their accuracy from 47.2 % [25/53] to 56.0 % [27/53] (P < 0.01). Both GPT-4o and Gemini 1.5 Pro correctly identified the imaging modality in 53/53 (100 %) and 51/53 (96.2 %) cases, respectively, but frequently failed to identify key imaging findings (43/53 cases [81.1 %] with incorrect identification of key imaging findings for GPT-4o and 50/53 [94.3 %] for Gemini 1.5). Radiologists show a specific ability to benefit from the integration of textual and visual information, whereas multimodal models mostly rely on the clinical context to suggest diagnoses.

This study aims to compare the diagnostic efficiency of the American College of Radiology-Thyroid Imaging, Reporting, and Data System (ACR-TIRADS), fine-needle aspiration (FNA) cytopathology alone, and the dynamic artificial intelligence (AI) diagnostic system. A total of 1035 patients from three hospitals were included in the study. Of these, 590 were from the retrospective dataset and 445 cases were from the prospective dataset. The diagnostic accuracy of the dynamic AI system in the thyroid nodules was evaluated in comparison to the gold standard of postoperative pathology. The sensitivity, specificity, ROC, and diagnostic differences in the κ-factor relative to the gold standard were analyzed for the AI system and the FNA. The dynamic AI diagnostic system showed good diagnostic stability in different ages and sexes and nodules of different sizes. The diagnostic AUC of the dynamic AI system showed a significant improvement from 0.89 to 0.93 compared to ACR TI-RADS. Compared to that of FNA cytopathology, the diagnostic efficacy of the dynamic AI system was found to be no statistical difference in both the retrospective cohort and the prospective cohort. The dynamic AI diagnostic system enhances the accuracy of ACR TI-RADS-based diagnoses and has the potential to replace biopsies, thus reducing the necessity for invasive procedures in patients.