Efficacy of PSMA PET/CT radiomics analysis for risk stratification in newly diagnosed prostate cancer: a multicenter study.
Authors
Affiliations (11)
Affiliations (11)
- The Persian Gulf Nuclear Medicine Research Center, Department of Nuclear Medicine, Molecular Imaging, and Theranostics, Bushehr Medical University Hospital, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran.
- Cancer Research Center, RAZAVI Hospital, Imam Reza International University, Mashhad, Iran.
- IoT and Signal Processing Research Group, ICT Research Institute, Faculty of Intelligent Systems Engineering and Data Science, Persian Gulf University, Bushehr, Iran.
- Department of Radiology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
- Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC V5Z 0B4, Canada.
- Khatam PET/CT Center, Tehran, Iran.
- Research Center for Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
- Department of Nuclear Medicine, Klinikum Westfalen, Dortmund, Germany.
- Department of Nuclear Medicine, Institute of Radiology, Neuroradiology and Nuclear Medicine, University Hospital Knappschaftskrankenhaus, Bochum, Germany.
- Department of Urology, Bushehr Medical University Hospital, Bushehr University of Medical Sciences, Bushehr, Iran.
- The Persian Gulf Nuclear Medicine Research Center, Department of Nuclear Medicine, Molecular Imaging, and Theranostics, Bushehr Medical University Hospital, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran. [email protected].
Abstract
Prostate-specific membrane antigen (PSMA) PET/CT plays an increasing role in prostate cancer management. Radiomics analysis of PSMA PET/CT images may provide additional information for risk stratification. This study aimed to evaluate the performance of PSMA PET/CT radiomics analysis in differentiating between Gleason Grade Groups (GGG 1–3 vs. GGG 4–5) and predicting PSA levels (below vs. at or above 20 ng/ml) in patients with newly diagnosed prostate cancer. In this multicenter study, patients with confirmed primary prostate cancer were enrolled who underwent [68Ga]Ga-PSMA PET/CT for staging. Inclusion criteria required intraprostatic lesions on PET and the International Society of Urological Pathology (ISUP) grade information. Three different segments were delineated including intraprostatic PSMA-avid lesions on PET, the whole prostate in PET, and the whole prostate in CT. Radiomic features (RFs) were extracted from all segments. Dimensionality reduction was achieved through principal component analysis (PCA) prior to model training on data from two centers (186 cases) with 10-fold cross-validation. Model performance was validated with external data set (57 cases) using various machine learning models including random forest, nearest centroid, support vector machine (SVM), calibrated classifier CV and logistic regression. In this retrospective study, 243 patients with a median age of 69 (range: 46–89) were enrolled. For distinguishing GGG 1–3 from GGG 4–5, the nearest centroid classifier using radiomic features (RFs) from whole-prostate PET achieved the best performance in the internal test set, while the random forest classifier using RFs from PSMA-avid lesions in PET performed best in the external test set. However, when considering both internal and external test sets, a calibrated classifier CV using RFs from PSMA-avid PET data showed slightly improved overall performance. Regarding PSA level classification (< 20 ng/ml vs. ≥20 ng/ml), the nearest centroid classifier using RFs from the whole prostate in PET achieved the best performance in the internal test set. In the external test set, the highest performance was observed using RFs derived from the concatenation of PET and CT. Notably, when combining both internal and external test sets, the best performance was again achieved with RFs from the concatenated PET/CT data. Our research suggests that [68Ga]Ga-PSMA PET/CT radiomic features, particularly features derived from intraprostatic PSMA-avid lesions, may provide valuable information for pre-biopsy risk stratification in newly diagnosed prostate cancer.