Association of Psychological Resilience With Decelerated Brain Aging in Cognitively Healthy World Trade Center Responders.
Authors
Affiliations (7)
Affiliations (7)
- Depression and Anxiety Center for Discovery and Treatment, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York.
- Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York.
- VISN 2 Mental Illness Research, Education, and Clinical Center, James J. Peters Veterans Affairs Medical Center, Bronx, New York.
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York.
- Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
- Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, Veterans Affairs Connecticut Health Care System, West Haven, Connecticut.
- Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut.
Abstract
Despite their exposure to potentially traumatic stressors, the majority of World Trade Center (WTC) responders-those who worked on rescue, recovery, and cleanup efforts on or following September 11, 2001-have shown psychological resilience, never developing long-term psychopathology. Psychological resilience may be protective against the earlier age-related cognitive changes associated with posttraumatic stress disorder (PTSD) in this cohort. In the current study, we calculated the difference between estimated brain age from structural magnetic resonance imaging (MRI) data and chronological age in WTC responders who participated in a parent functional MRI study of resilience (<i>N</i> = 97). We hypothesized that highly resilient responders would show the least brain aging and explored associations between brain aging and psychological and cognitive measures. WTC responders screened for the absence of cognitive impairment were classified into 3 groups: a WTC-related PTSD group (<i>n</i> = 32), a Highly Resilient group without lifetime psychopathology despite high WTC-related exposure (<i>n</i> = 34), and a Lower WTC-Exposed control group also without lifetime psychopathology (<i>n</i> = 31). We used <i>BrainStructureAges</i>, a deep learning algorithm that estimates voxelwise age from T1-weighted MRI data to calculate decelerated (or accelerated) brain aging relative to chronological age. Globally, brain aging was decelerated in the Highly Resilient group and accelerated in the PTSD group, with a significant group difference (<i>p</i> = .021, Cohen's <i>d</i> = 0.58); the Lower WTC-Exposed control group exhibited no significant brain age gap or group difference. Lesser brain aging was associated with resilience-linked factors including lower emotional suppression, greater optimism, and better verbal learning. Cognitively healthy WTC responders show differences in brain aging related to resilience and PTSD.