Multiparametric ultrasound techniques are superior to AI-assisted ultrasound for assessment of solid thyroid nodules: a prospective study.

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Abstract

To evaluate the diagnostic performance of multiparametric ultrasound (mpUS) and AI-assisted B-mode ultrasound (AI-US), and their potential to reduce unnecessary biopsies to B-mode for solid thyroid nodules. This prospective study enrolled 226 solid thyroid nodules with 145 malignant and 81 benign pathological results from 189 patients (35 men and 154 women; age range, 19-73 years; mean age, 45 years). Each nodule was examined using B-mode, microvascular flow imaging (MVFI), elastography with elasticity contrast index (ECI), and an AI system. Image data were recorded for each modality. Ten readers with different experience levels independently evaluated the B-mode images of each nodule to make a "benign" or "malignant" diagnosis in both an unblinded and blinded manner to the AI reports. The most accurate ECI value and MVFI mode were selected and combined with the dichotomous prediction of all readers. Descriptive statistics and AUCs were used to evaluate the diagnostic performances of mpUS and AI-US. Triple mpUS with B-mode, MVFI, and ECI exhibited the highest diagnostic performance (average AUC = 0.811 vs. 0.677 for B-mode, p = 0.001), followed by AI-US (average AUC = 0.718, p = 0.315). Triple mpUS significantly reduced the unnecessary biopsy rate by up to 12% (p = 0.007). AUC and specificity were significantly higher for triple mpUS than for AI-US mode (both p < 0.05). Compared to AI-US, triple mpUS (B-mode, MVFI, and ECI) exhibited better diagnostic performance for thyroid cancer diagnosis, and resulted in a significant reduction in unnecessary biopsy rate. AI systems are expected to take advantage of multi-modal information to facilitate diagnoses.

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