Back to all news

Imaging Reveals Skull Changes and Immune Impact in Glioblastoma

EurekAlertResearch
Imaging Reveals Skull Changes and Immune Impact in Glioblastoma

Advanced imaging uncovers that glioblastoma affects the skull and immune system, not just the brain.

Key Details

  • 1Montefiore Einstein researchers found glioblastoma erodes skull bones and alters skull marrow immune makeup.
  • 2CT imaging of patients showed similar skull erosions as seen in mouse models with glioblastoma.
  • 3Single-cell RNA sequencing revealed a shift toward pro-inflammatory immune cells in the skull marrow.
  • 4FDA-approved osteoporosis drugs halted skull erosion but made tumors more aggressive and impaired immunotherapy effects.
  • 5Findings suggest glioblastoma should be seen as a systemic, not just local, disease.

Why It Matters

These findings highlight the need for radiologists to consider extracranial effects when imaging glioblastoma and suggest that traditional local-treatment approaches may overlook critical systemic interactions. Understanding these effects can influence both diagnostic imaging strategies and future treatment planning.

Ready to Sharpen Your Edge?

Join hundreds of your peers who rely on RadAI Slice. Get the essential weekly briefing that empowers you to navigate the future of radiology.

We respect your privacy. Unsubscribe at any time.