AI misses 14% of invasive breast cancers on mammography, with luminal cancers and dense tissue posing significant challenges.
Key Details
- 1Study analyzed 1,097 breast cancers from 1,082 women using Lunit Insight MMG AI between 2014–2020.
- 2AI missed 154 cancers (14%), often in younger women with smaller (<2 cm), lower-grade tumors and dense breasts.
- 3Missed cancers were more likely luminal subtype (false-negative rate 17.2%), compared to HER2-enriched (9%) and triple-negative (14.5%).
- 4Major reasons for AI misses included dense breast tissue (n=56), nonmammary zone location (n=22), architectural distortion (n=12), and amorphous calcifications (n=5).
- 561.7% of AI-missed cancers were deemed 'actionable' on further review by radiologists.
Why It Matters

Source
AuntMinnie
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